Table 1 Summary of radiogenomics papers focusing on High Grade Serous Ovarian Cancer (HGSOC). CLOVAR refers to the Classification of Ovarian Cancer proposed in [41]

Regular association

[42]

108

CT

Genomics

BRCA mutation

Nodular pelvic disease and the presence of pelvic disease in the gastrohepatic ligament associated with high likelihood of BRCA.

Infiltrative pelvic disease, mesenteric presence and supradiaphragmatic lymphadenopathy were related with less likelihood of BRCA mutation.

[43]

38

CT

Genomics

19q12 amplification

High inter lesion heterogeneity is associated with the amplification of 19q12.

[44]

46

CT

Transcriptomics

CLOVAR classification

Peritoneal disease and mesenteric infiltration related with the mesenchymal subtype of the CLOVAR.

[45]

92

CT

Transcriptomics

CLOVAR classification

Peritoneal involvement and presence of disease in the pelvis and ovary related with mesenchymal subtype.

[46]

20

CT

Proteomics

Selected proteins

Intra- and inter-site heterogeneity associated with selected proteins involved in aminoacid metabolism.

[47]

297

CT

Multilevel

DNA damage and stromal phenotype

CT-based radiomic signature with prognostic capacity positively associated with a stromal phenotype and negatively correlated with markers of DNA damage.

Targeted analysis

[48]

1

MRI

Multilevel

Histology and genomics

Different imaging habitats were related to different growth patterns when looking at the histopathological examination. Hypoxia and neovascularisation markers also differ between habitats.

Using presence of somatic mutations and gene copy number variation, phylogenetic tree reconstruction showed that the habitats derive from different clones.