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Table 2 Physico-chemical features of the gadoterate, gadobutrol, and gadoteridol molecules

From: Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats

 Gadoterate (Dotarem/Clariscan)Gadobutrol (Gadovist)Gadoteridol (ProHance)
kd (s−1)a7.17 × 10−141.11 × 10− 121.15 × 10− 11
t½ (years)b306,54919,8011911
Hydrophilic Surface (Å2)491404353
Solvation enthalpy (kcal/mol)˗36˗12˗9
  1. akd are the rate constants that characterize the dissociation of GBCA complexes in 0.15 M NaCl at 25 °C and pH = 7.4 [43, 44]
  2. bt½ is the half-life (years) of the dissociation reactions of GBCA complexes in 0.15 M NaCl at 25 °C and pH = 7.4 (t½ = ln2/kd) [43, 44]