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Insights into Imaging

Table 2 Physico-chemical features of the gadoterate, gadobutrol, and gadoteridol molecules

From: Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats

 

Gadoterate (Dotarem/Clariscan)

Gadobutrol (Gadovist)

Gadoteridol (ProHance)

kd (s−1)a

7.17 × 10−14

1.11 × 10− 12

1.15 × 10− 11

t½ (years)b

306,549

19,801

1911

Hydrophilic Surface (Ã…2)

491

404

353

Solvation enthalpy (kcal/mol)

Ë—36

Ë—12

Ë—9

  1. akd are the rate constants that characterize the dissociation of GBCA complexes in 0.15 M NaCl at 25 °C and pH = 7.4 [43, 44]
  2. bt½ is the half-life (years) of the dissociation reactions of GBCA complexes in 0.15 M NaCl at 25 °C and pH = 7.4 (t½ = ln2/kd) [43, 44]
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