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Table 6 Bone marrow burden (BMB) classification

From: Imaging of non-neuronopathic Gaucher disease: recent advances in quantitative imaging and comprehensive assessment of disease involvement

 

Femurs

Lumbar spine

Involvement

Site

Score

Site

Score

 

Diaphysis

1

Patchy

1

 

Proximal epiphysis/apophysis

2

Diffuse

2

 

Distal epiphysis

3

Absence of fat in basiverteral region

1

Sequence

Signal intensitya

Score

Signal intensityb

Score

T2-weighted, (or, STIR)c

Hyperintense

2 (2)

Hyperintense

2 (2)

Slightly hyperintense

1 (1)

Slightly hyperintense

1 (1)

Isointense

0 (0)

Isointense

0 (0)

Slightly hypointense

1 (N/A)

Slightly hypointense

1 (N/A)

Hypointense

2 (N/A)

Hypointense

2 (N/A)

Mixed type

3 (3)

  

T1-weighted

Slightly hyperintense or isointense

0

Slightly hyperintense

0

Slightly hypointense

1

Isointense

1

Hypointense

2

Slightly hypointense

2

  

Hypointense

3

 

Sum

 

Sum

  1. aRelative to subcutaneous fat
  2. bRelative to normal intervertebral disc
  3. cModified BMB scoring with STIR instead of T2-weighted imaging, adjusted scoring indicated in parentheses