Fig. 20
A 70-year-old woman with high-grade serous ovarian cancer who underwent FDG-PET/CT (standardized uptake value map of the fluorodeoxyglucose uptake [FDG SUV] is showed) and MRI, which included T2, diffusion (DWI), and dynamic contrast-enhanced (DCE) sequences (images on the left) showing a primary ovarian mass as well as multiple peritoneal/serosal implants including in the cul-de-sac. A composite “habitat” map of the implant in the cul-de-sac was performed (right) containing three clusters derived from PET and MRI data. Tissue sampling from each cluster represented by a different color on the habitat map demonstrated genomic heterogeneity underpinning the phenotypic heterogeneity observed on imaging