Table 1 Different type of gastrointestinal tract lesions associated with NF1
From: Spectrum of gastrointestinal lesions of neurofibromatosis type 1: a pictorial review
True neurogenic neoplasm | Solitary neurofibroma Diffuse or plexiform neurofibroma Gastric schwannoma (1 case reported) Diffuse mucosal/submucosal neurofibromatosis Ganglioneuromatosis Gangliocytic paraganglioma Malignant peripheral nerve sheath tumour (very rare) |
Interstitial cell of Cajal lesions | Multifocal clinical gastrointestinal stromal tumours (GISTs) Minute incidental GIST tumourlets (usually non-gastric) Microscopic diffuse or multifocal interstitial cell of Cajal hyperplasia Motility disorders related to Cajal cell lesions |
Neuroendocrine tumours | Carcinoid tumours at any gastrointestinal location Periampullary somatostatinoma Rarely, insulinoma and gastrinoma |
Miscellaneous neoplasms and lesions | Adenocarcinoma at different gastrointestinal sites Vasculopathy |