Table 1 The key epidemiological, clinical and pathological differences between type 1 and type 2 autoimmune pancreatitis
From: Abdominal manifestations of IgG4-related disease: a pictorial review
Type 1 AIP | Type 2 AIP | |
|---|---|---|
Gender | Male > female | Male = Female |
Age | Older (6th decade) | Younger (4th decade) |
Clinical Presentation | Painless obstructive jaundice | Painless obstructive jaundice, acute pancreatitis and abdominal pain |
Histology | IgG4-rich periductal lymphoplasmocytic infiltrates | Granulocyte epithelial lesions (GEL) |
Serum IgG4 | Usually elevated | Normal |
Extrapancreatic involvement | Salivary glands, biliary tree, kidneys, retroperitoneum | None |
Treatment outcome | Excellent response to steroid, but recurrence is common | Excellent response to steroid, and recurrence is rare |