Fig. 14

The arrows show an area of mild, low-signal intensity on T2-weighted imaging (a), with restricted diffusion on DWI (b) and in the ADC map (c). This corresponds to a hyperintense area on pre-contrast T1-weighted imaging (d), which is consistent with the products from the haemoglobin degradation after biopsy, as also supported by the post-contrast subtraction imaging (e) and in the colour DCE map (f). DCE studies have been obtained by gradient-echo sequences (TR: 4,5 ms; TE: 1,5 ms; flip angle: 15°; Average: 4; slice thickness: 2 mm; Matrix: 320 × 320; Scan Time: 3.13 min), using a body-weight adjusted intravenous bolus of gadobutrol (Gadovist, 1 mmol/mL; Bayer Schering Pharma, Berlin, Germany). DWI parameters were: TR ≥ 3000 ms; TE ≤ 90 ms; slice thickness ≤ 4 mm, no gap; field of view:160–220 mm; in plane dimension ≤ 2.5 mm phase and frequency; b values for DWI were 0–500- and values ranging between 1000 and 3000 s/mm². For ADC maps, if only two b values can be acquired, it is preferred that the lowest b value should be set at 50–100 s/mm² and the highest should be 800–1000 s/mm²