Fig. 10

This figure displays the change in signal intensity on b images and ADC value during the disease course from monoclonal gammopathy of undetermined significance, over smouldering to myeloma-infiltrated bone marrow with plasma cell percentages of 10-25 %, 25-50 % and >50 %, followed by the changes early and late after therapy, and compared to normal red and yellow marrow. The different diffusion characteristics are explained by changes in the amount of fat and interstitial water, with an increasing water proton diffusivity as fat decreases and interstitial water increases