Table 2 Biological correlation of perfusion-related parameters
From: Advanced imaging of colorectal cancer: From anatomy to molecular imaging
BV and BF (often coupled) | Permeability | Biological interpretation |
|---|---|---|
↑↑↑ | ↓ or ↔ or ↑ | New vessel formation (increased perfusion and blood volume) with varying degrees of maturation |
↓ or ↔ or ↑ | ↑↑↑ | Poor perfusion with increased permeability (immature vessels), which usually represent a reaction to hypoxia |
↑ | ↔ or ↓ | Mature vasculature |
↑ | ↔ or ↑ | Inflammation +/− early fibrosis |
↓ | ↓ | Mature fibrotic areas (usually showing a progressive enhancement) |
↓↓ | ↓↓ | Poor vascularized areas |
BF↓ relating to BV | ---- | Blood flow-blood volume mismatch, which usually represents hypoxia |
+/− 0 | +/− 0 | Necrotic areas |