Table 1 Histological variants of invasive lobular carcinoma
Subtype | Histological features |
|---|---|
Alveolar | Small cells arranged in more-or-less globular aggregate of 20 or more cells separated by thin bands of fibrous stroma. |
Tubulo-lobular | Neoplastic cells form tubular, glandular structures. The best prognosis among all forms. |
Solid | Solid sheets of uniform small cells showing lobular morphology. |
There are more pleomorphism and higher frequency of mitoses. | |
Pleomorphic | The more aggressive and worst prognosis. |
The histological pattern may mimic an undifferentiated ductal carcinoma. Cells are larger due to irregular nuclei with prominent nucleoli. | |
Mitotic figures are frequent, disperse or in line, throughout the breast stroma. Apocrine or histiocytoid differentiation is common. |