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Insights into Imaging
Fig. 3 | Insights into Imaging

Fig. 3

From: Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods

Fig. 3

A 40-year-old woman with previous surgical resection of an ILC 15 months ago. Mammogram (not shown) with architectural distortion, possibly surgical-related change. a MR image axial T1, 3rd min, post-contrast media. There is a collection with low signal (+) and marked wash-in enhancement surrounding the surgical area. A new surgical exploration showed LN. b Photomicrograph H-E stain, ×200, pagetoid ductal spread, with lobular proliferation, extending to the duct, between the basal membrane and epithelial cell (arrowhead). In c the epithelial cells show marked reactivity expression for e-cadherin and e-cadherin-negative LCIS cells (*)

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