Fig. 2

A 47-year-old woman; percutaneous sample shows LN (LCIS and ALH). The final diagnosis was confirmed by surgical biopsy. a Mammography in cranio-caudal view reveals a focal asymmetry with subtle architectural distortion in the lateral quadrant. b Histological H-E stain slice (×100) with marked lobular distention and discohesive cells. c Immunohistochemical (IHC)—photomicrography staining (×40) for e-cadherin showing no expression in acini involved by LN, on the left and strong expression on preserved acini, on the right (+). d IHC for smooth muscle actin (×200), a myoepithelial membrane marker. There is strong reactivity for the cytoplasm of basal membrane, confirming an intact layer of epithelial cells without invasion. Notice the marked loss of cell cohesion, without forming papillary or cribriform arrangement like in some of DCIS