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Insights into Imaging
Fig. 1 | Insights into Imaging

Fig. 1

From: Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods

Fig. 1

a Schematic drawing: 1 sagittal view of the breast showing terminal duct-lobular units converging to lactiferous ducts and papilla; 2 a normal terminal duct-lobular unit (TDLU); 3 atypical lobular hyperplasia (ALH), cellular proliferation in less than 50 % of acini; 4 lobular carcinoma in situ (LCIS) cellular proliferation expanding more than a half of acini within a TDLU. (b) ALH in histological slice (haematoxylin–eosin [H-E] stain, ×40 photomicrograph) demonstrating some normal acini (*) and some lobules distended by cell proliferation (black arrowheads). c LCIS in histological slice H-E, ×200, showing all acini filled and distended by an uniform cell population

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