Table 3 Classic and modified Boston criteria [11, 19]
Classic Boston criteria | Modified Boston criteria | |
|---|---|---|
Definite CAA | Full post-mortem examination demonstrating: | No modification |
- Lobar, cortical or corticosubcortical haemorrhage | ||
- Severe CAA with vasculopathy | ||
- Absence of other diagnostic lesion | ||
Probable CAA with supporting pathology | Clinical data and pathological tissue (evaluated) haematoma or cortical biopsy) demonstrating: | No modification |
- Lobar, cortical or corticosubcortical haemorrhage | ||
- Some degree of CAA in specimen | ||
- Absence of other diagnostic lesion | ||
Probable CAA | Clinical data and MRI or CT demonstrating: | Clinical data and MRI or CT demonstrating: |
- Multiple haemorrhages restricted to lobar, cortical or corticosubcortical regions (cerebellar haemorrhage allowed) | - Multiple haemorrhages restricted to lobar, cortical or corticosubcortical regions (cerebellar haemorrhage allowed), or | |
- Age ≥55 | - Single lobar, cortical, or corticosubcortical haemorrhage and focal or disseminated superficial siderosis | |
- Absence of other cause of haemorrhage | - Age ≥55 | |
- Absence of other cause of haemorrhage or superficial siderosis | ||
Possible CAA | Clinical data and MRI or CT demonstrating: | Clinical data and MRI or CT demonstrating: |
- Single lobar, cortical or corticosubcortical haemorrhage | - Single lobar, cortical or corticosubcortical haemorrhage, or | |
- Age ≥55 | - Focal or disseminated superficial siderosis | |
- Absence of other cause of haemorrhage | - Age ≥55 | |
- Absence of other cause of haemorrhage or superficial siderosis |