Table 2 Standard MRI protocol for the diagnosis of CAA
Sequence | Expected role for the diagnosis |
|---|---|
Minimum required protocol | |
T2*-weighted image | Depiction of haemosiderin depositions suggestive of chronic ICHs, MBs and SS |
Fluid-attenuated inversion recovery image | Depiction of acute and subacute SAHs, and white matter signal changes |
Diffusion-weighted image | Depiction of acute microinfarction Evaluation of vasogenic oedema due to CAA-related inflammation |
Optional sequence for the diagnosis of CAA | |
Susceptibility-weighted image | Depiction of haemosiderin depositions, clearer than T2*-weighted image |
Additional sequences for differential diagnosis | |
T1-weighted image | Depiction of T1 shortening due to methaemoglobin and melanin |
Contrast-enhanced T1-weighted image | Differentiation between haemorrhagic tumours and other lesions |
Magnetic resonance angiogram | Evaluation of vascular disorders such as vasculitis |