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Table 1 CAA-related abnormal imaging findings

From: Imaging spectrum of sporadic cerebral amyloid angiopathy: multifaceted features of a single pathological condition

Disease

Imaging findings

Recommended neuroimaging modality

ICH

Haematoma with distinctive cortical-subcortical distribution generally sparing the deep white matter and basal ganglia and brainstem

CT and MRI

MRI; additional depiction of chronic haemosiderin depositions and MBs

MBs

Small round hypointense foci on MRI

MRI, especially susceptibility-weighted image

SAH

Supratentorial sulcal high attenuation/intensity, most frequently depicted around the precentral gyrus

CT and MRI

MRI; additional depiction of MB and SS

SS

Hypointensity along the supratentorial cerebral sulcus on MRI

MRI, especially susceptibility-weighted image

CAA-related inflammation

Large confluent asymmetric abnormal attenuation/intensity mainly in the subcortical WM

CT and MRI

MRI; additional evaluation of vasogenic oedema and other findings such as MB and SS

Leukoaraiosis

Low attenuation on CT and high intensity on FLAIR and T2W MRI mainly in the deep WM with sparing of the subcortical U fibres

CT and MRI

MRI; depiction of leukoaraiosis clearer than CT

Microinfarction

Small ovoid or round high intensity of the subcortical and cortex on diffusion-weighted image

MRI, especially diffusion-weighted image

  1. CAA cerebral amyloid angiopathy, CT computed tomography, FLAIR fluid-attenuated inversion recovery, ICH intracerebral haemorrhage, MRI magnetic resonance imaging, MB microbleed, SAH subarachnoid haemorrhage, SS superficial siderosis, T2W T2-weighted, WM white matter