Fig. 20
From: Imaging findings of mucopolysaccharidoses: a pictorial review
MRS. (Legend: mIns = myo-inositol; Cho = choline; Cr = creatine; NAA = N-acetyl-aspartate). Multivoxel MRS performed on an MPS VI patient; after post-processing analysis, two spectroscopic graphics are shown in a and c (corresponding voxels in b and d). The mIns/Cr ratio was found to have slightly increased in the white matter lesion and in the gray matter area (respectively values of 0.68 and 0.59). As reported by Vedolin et al. [39], cerebral GAG deposition induces changes in glial cells, with a consequent increase in the mIns/Cr ratio