Short-term PET-derived kinetic estimation for the diagnosis of hepatocellular carcinoma: a combination of the maximum-slope method and dual-input three-compartment model

Insights into Imaging

Table 4 ¹⁸F-FDG PET-derived kinetic parameters obtained using the combined model of liver tissues between HCC patients and healthy volunteers

Parameters	Cirrhosis n = 21	Normal liver tissue n = 81	AUC	p
HPI (%)	42.76 ± 17.08	18.02 ± 11.52	0.958	< 0.001
K₁ (mL/min/mL)	1.00 ± 0.63	1.36 ± 0.40	0.716	0.020
k₂ (1/mL)	1.01 ± 0.59	1.37 ± 0.44	0.685	0.026
k₃ (1/mL)	0.005 ± 0.007	0.030 ± 0.036	0.815	0.002
k₄ (1/mL)	0.023 ± 0.034	0.036 ± 0.037	0.591	0.154
\({V}_{\mathrm{b}}\) (unitless)	0.003 ± 0.007	0.025 ± 0.065	0.961	< 0.001