Focal breast edema and breast edema score on T2-weighted images provides valuable biological information for invasive breast cancer

Chen, Yanhong; Wang, Lijun; Luo, Ran; Liu, Huanhuan; Zhang, Yuzhen; Wang, Dengbin

doi:10.1186/s13244-023-01424-7

Insights into Imaging

Table 3 Clinical-pathological features of invasive breast cancer with different breast edema score

From: Focal breast edema and breast edema score on T2-weighted images provides valuable biological information for invasive breast cancer

	BES1	BES2	BES3	BES4	p value	Intergroup comparison
	(n = 103)	(n = 55)	(n = 31)	(n = 16)	p value	BES 1 versus 2	BES 1 versus 3	BES 1 versus 4	BES 2 versus 3	BES 2 versus 4	BES 3 versus 4
Age in years	57.0 ± 12.0	58.5 ± 12.1	56.0 ± 11.3	64.6 ± 9.2	0.256	0.483	0.679	0.017	0.365	0.064	0.012
Tumor size on MRI in cm	1.9 ± 0.9	2.3 ± 0.8	3.3 ± 1.4	2.5 ± 0.9	< 0.001	0.483	< 0.001	0.007	< 0.001	0.216	0.058
cT stage
T1	73	25	4	7	< 0.001	0.002	< 0.001	0.032	0.002	0.904	0.045
T2–3	30	30	27	9
Grade*
WHO I/II	54	24	9	6	0.006	0.117	0.014	0.077	0.268	0.493	0.823
III	26	21	14	8
ER
Status in percentage	74.4 ± 31.3	46.6 ± 45.7	39.3 ± 41.7	46.6 ± 45.7	< 0.001	0.061	< 0.001	0.075	0.019	0.222	0.581
Negative	11	14	13	6	< 0.001	0.015	< 0.001	0.014	0.114	0.531	0.769
Positive	92	41	18	10
PR
Status in percentage	54.1 ± 35.4	38.9 ± 37.6	18.35 ± 28.5	24.4 ± 31.6	< 0.001	0.013	< 0.001	0.002	0.013	0.215	0.511
Negative	18	16	15	6	0.001	0.091	< 0.001	0.128	0.074	0.739	0.477
Positive	85	39	16	10
Ki-67
Status in percentage	21.6 ± 17.6	29.1 ± 20.5	43.5 ± 23.1	27.3 ± 17.8	< 0.001	0.018	< 0.001	0.230	0.004	0.757	0.018
Low < 14%	51	19	3	5	< 0.001	0.071	< 0.001	0.173	0.011	0.806	0.146
High ≥ 14%	52	36	28	11
HER-2
Negative	92	47	22	11	0.007	0.477	0.026	0.064	0.105	0.249	1.000
Positive	11	8	9	5
LN status
Negative	78	39	15	9	0.074	0.510	0.004	0.183	0.038	0.270	0.609
Positive	25	16	16	7
pN stage
N0	78	39	15	9	0.007
N1	19	8	4	2
N2–3	5	6	6	3
LVI
Negative	98	49	27	14	0.055	0.273	0.246	0.238	1.000	1.000	1.000
Positive	5	6	4	2
Molecular subtype
Luminal	10	13	13	5	< 0.001	0.018	< 0.001	0.044	0.076	0.772	0.475
Non-luminal	93	42	18	11

Statistically signifcant p-values are bolded
*Data from 43 patients were unavailable

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