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Table 3 Meta-analytic pooled indices of diagnostic test accuracy for the individual MRI features

From: Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis

MRI feature

No. of studies

Summary estimates

Sensitivity % (95% CI), I2%

Specificity % (95% CI), I2%

PLR (95% CI)

NLR (95% CI)

Bulging prostatic contour

6

53.0 (36.6–68.7), 82.2

83.1 (71.6–90.6), 81.5

3.1 (2.2–4.4)

0.6 (0.4–0.7)

Irregular or spiculated margin

9

28.4 (16.3–44.7), 93.7

85.2 (79.3–89.6), 85.4

1.9 (1.2–3.0)

0.8 (0.7–1.0)

Asymmetry or invasion of neurovascular bundle

7

28.0 (19.0–39.3), 75.5

95.1 (87.9–98.1), 92.3

5.7 (2.8–11.6)

0.8 (0.7–0.8)

Obliteration of rectoprostatic angle

5

26.3 (14.8–42.2), 77.0

94.5 (88.6–97.4), 61.7

4.8 (3.0–7.5)

0.8 (0.7–0.9)

Tumor-capsule interface > 10 mm

8

86.3 (70.0–94.4), 87.7

62.5 (47.3–75.6), 92.6

2.3 (1.7–3.1)

0.2 (0.1–0.4)

Breach of the capsule with direct tumor extension

9

23.7 (14.8–35.8), 93.0

98.0 (96.2–99.0), 78.1

12.1 (6.4–23.0)

0.8 (0.7–0.9)

  1. MRI, magnetic resonance imaging; CI, confidence interval; PLR, positive likelihood ratio; LNR, negative likelihood ratio