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Table 1 Characteristics of all the patients

From: A clinical–radiomics model based on noncontrast computed tomography to predict hemorrhagic transformation after stroke by machine learning: a multicenter study

Variables

Overall (n = 517)

Training cohort (n = 355)

Internal validation cohort (n = 90)

External validation cohort (n = 72)

p

Gender, n (%)

    

0.039

Male

333 (64.4)

234 (65.9)

62 (68.9)

37 (51.4)

 

Female

184 (35.6)

121 (34.1)

28 (31.1)

35 (48.6)

 

age, years, mean ± SD

67.02 ± 12.67

67.19 ± 12.39

66.83 ± 12.15

66.44 ± 14.70

0.891

Smoking index, mean ± SD

307.23 ± 633.55

325.51 ± 662.15

226.72 ± 428.54

317.78 ± 700.63

0.414

drinking index, mean ± SD

1270.36 ± 3193.83

1268.38 ± 3107.17

1443.89 ± 3768.48

1063.19 ± 2848.41

0.753

Previous stroke, n (%)

    

0.144

No

417 (80.7)

292 (82.3)

73 (81.1)

52 (72.2)

 

Yes

100 (19.3)

63 (17.7)

17 (18.9)

20 (27.8)

 

Diabetes mellitus, n (%)

    

0.192

No

368 (71.2)

258 (72.7)

57 (63.3)

53 (73.6)

 

Yes

149 (28.8)

97 (27.3)

33 (36.7)

19 (26.4)

 

Atrial-fibrillation, n (%)

    

0.193

No

410 (79.3)

289 (81.4)

66 (73.3)

55 (76.4)

 

Yes

107 (20.7)

66 (18.6)

24 (26.7)

17 (23.6)

 

OTC, hours, mean ± SD

5.43 ± 2.77

5.20 ± 2.49

5.68 ± 3.01

6.25 ± 3.51

0.008

SBP, mm Hg, mean ± SD

152.32 ± 24.41

153.45 ± 24.01

150.39 ± 27.32

149.18 ± 22.41

0.285

DBP, mm Hg, mean ± SD

86.97 ± 13.58

87.68 ± 13.03

85.48 ± 15.46

85.37 ± 13.67

0.217

Baseline NIHSS, mean ± SD

9.15 ± 7.17

9.18 ± 7.07

9.87 ± 7.91

8.09 ± 6.61

0.288

Hgb, g/L, mean ± SD

135.40 ± 53.00

136.38 ± 62.78

134.90 ± 17.77

131.21 ± 18.60

0.749

PLT, 109/L, mean ± SD

209.67 ± 82.15

211.25 ± 84.67

210.68 ± 84.28

200.65 ± 65.56

0.604

WBC, 109/L, mean ± SD

8.75 ± 3.77

8.65 ± 3.87

8.95 ± 3.52

8.99 ± 3.57

0.679

Neu, 109/L, mean ± SD

6.47 ± 3.79

6.47 ± 4.08

6.80 ± 3.40

6.07 ± 2.60

0.483

Ly, 109/L, mean ± SD

1.54 ± 1.15

1.49 ± 0.81

1.64 ± 2.01

1.66 ± 1.11

0.327

Mn, 109/L, mean ± SD

0.59 ± 0.54

0.61 ± 0.63

0.58 ± 0.27

0.50 ± 0.16

0.27

N/M, mean ± SD

5.80 ± 6.19

5.81 ± 6.50

6.34 ± 6.30

5.08 ± 4.13

0.436

L/M, mean ± SD

3.28 ± 3.05

3.14 ± 2.65

3.42 ± 4.36

3.76 ± 2.86

0.266

Eon, 109/L, mean ± SD

0.14 ± 0.25

0.13 ± 0.18

0.16 ± 0.27

0.19 ± 0.44

0.079

TC, mmol/L, mean ± SD

4.56 ± 1.20

4.62 ± 1.17

4.52 ± 1.36

4.32 ± 1.11

0.159

TG, mmol/L, mean ± SD

1.65 ± 1.29

1.63 ± 1.29

1.90 ± 1.61

1.49 ± 0.69

0.1

HDL, mmol/L, mean ± SD

1.23 ± 0.46

1.24 ± 0.49

1.21 ± 0.42

1.19 ± 0.38

0.606

LDL, mmol/L, mean ± SD

2.78 ± 0.97

2.83 ± 0.94

2.70 ± 1.10

2.62 ± 0.97

0.176

BUN, mmol/L, mean ± SD

6.35 ± 3.42

6.42 ± 3.62

6.34 ± 3.30

6.02 ± 2.46

0.666

Cr, μmol/L, mean ± SD

80.75 ± 49.30

83.96 ± 55.50

75.36 ± 33.78

71.66 ± 26.41

0.081

Glu, mmol/L, mean ± SD

7.88 ± 3.44

7.74 ± 3.30

8.55 ± 3.88

7.74 ± 3.47

0.13

HbA1c, %, mean ± SD

7.95 ± 6.31

8.19 ± 7.45

7.54 ± 2.09

7.33 ± 2.60

0.46

INR, mean ± SD

1.02 ± 0.15

1.01 ± 0.12

1.03 ± 0.18

1.05 ± 0.19

0.198

FDPs, μg/mL, mean ± SD

6.67 ± 12.96

7.00 ± 14.23

5.51 ± 8.57

6.53 ± 10.78

0.618

D-Dimer, mg/L, mean ± SD

2.53 ± 5.39

2.73 ± 6.03

2.29 ± 4.27

1.85 ± 2.52

0.403

NT-proBNP, mean ± SD

1062.22 ± 2025.72

1048.42 ± 2026.11

1192.05 ± 2145.51

967.99 ± 1885.10

0.763

TOAST types, n (%)

    

0.463

LAA

300 (58.0)

210 (59.2)

51 (56.7)

39 (54.2)

 

CE

151 (29.2)

106 (29.9)

26 (28.9)

19 (26.4)

 

SVO

48 (9.3)

29 (8.2)

8 (8.9)

11 (15.3)

 

SOE

5 (1.0)

4 (1.1)

1 (1.1)

0 (0.0)

 

SUE

13 (2.5)

6 (1.7)

4 (4.4)

3 (4.2)

 
  1. Categorical variables are represented by the number (percent), and continuous variables are represented by mean (± standard deviation)
  2. OTC, onset-to-CT time; SBP, systolic blood pressure; DBP, diastolic blood pressure; NIHSS, National Institute of Health Stroke Scale; Hgb, Hemoglobin; PLT, Blood platelet; WBC, white blood cell; Neu, neutrophil; Ly, lymphocyte; Mn, monocyte; N/M, neutrophil-monocyte ratio; L/M, lymphocyte-monocyte ratio; Eon, eosinophils; TC, total cholesterol; TG, triglycerides; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; BUN, blood urea nitrogen; Cr, Creatinine; Glu, Glucose; HbA1c, glycated hemoglobin A1c; INR, international normalized ratio; FDPs, fibrin degradation products; NT-proBNP, N-terminal pro-brain natriuretic peptide, ng/L; LAA, large artery atherosclerosis; SVO, small vessel occlusion; CE, cardioembolism; SOE, stroke of other determined etiology; SUE, stroke of undetermined etiology