Variables | Overall (n = 517) | Training cohort (n = 355) | Internal validation cohort (n = 90) | External validation cohort (n = 72) | p |
---|---|---|---|---|---|
Gender, n (%) | 0.039 | ||||
Male | 333 (64.4) | 234 (65.9) | 62 (68.9) | 37 (51.4) | |
Female | 184 (35.6) | 121 (34.1) | 28 (31.1) | 35 (48.6) | |
age, years, mean ± SD | 67.02 ± 12.67 | 67.19 ± 12.39 | 66.83 ± 12.15 | 66.44 ± 14.70 | 0.891 |
Smoking index, mean ± SD | 307.23 ± 633.55 | 325.51 ± 662.15 | 226.72 ± 428.54 | 317.78 ± 700.63 | 0.414 |
drinking index, mean ± SD | 1270.36 ± 3193.83 | 1268.38 ± 3107.17 | 1443.89 ± 3768.48 | 1063.19 ± 2848.41 | 0.753 |
Previous stroke, n (%) | 0.144 | ||||
No | 417 (80.7) | 292 (82.3) | 73 (81.1) | 52 (72.2) | |
Yes | 100 (19.3) | 63 (17.7) | 17 (18.9) | 20 (27.8) | |
Diabetes mellitus, n (%) | 0.192 | ||||
No | 368 (71.2) | 258 (72.7) | 57 (63.3) | 53 (73.6) | |
Yes | 149 (28.8) | 97 (27.3) | 33 (36.7) | 19 (26.4) | |
Atrial-fibrillation, n (%) | 0.193 | ||||
No | 410 (79.3) | 289 (81.4) | 66 (73.3) | 55 (76.4) | |
Yes | 107 (20.7) | 66 (18.6) | 24 (26.7) | 17 (23.6) | |
OTC, hours, mean ± SD | 5.43 ± 2.77 | 5.20 ± 2.49 | 5.68 ± 3.01 | 6.25 ± 3.51 | 0.008 |
SBP, mm Hg, mean ± SD | 152.32 ± 24.41 | 153.45 ± 24.01 | 150.39 ± 27.32 | 149.18 ± 22.41 | 0.285 |
DBP, mm Hg, mean ± SD | 86.97 ± 13.58 | 87.68 ± 13.03 | 85.48 ± 15.46 | 85.37 ± 13.67 | 0.217 |
Baseline NIHSS, mean ± SD | 9.15 ± 7.17 | 9.18 ± 7.07 | 9.87 ± 7.91 | 8.09 ± 6.61 | 0.288 |
Hgb, g/L, mean ± SD | 135.40 ± 53.00 | 136.38 ± 62.78 | 134.90 ± 17.77 | 131.21 ± 18.60 | 0.749 |
PLT, 109/L, mean ± SD | 209.67 ± 82.15 | 211.25 ± 84.67 | 210.68 ± 84.28 | 200.65 ± 65.56 | 0.604 |
WBC, 109/L, mean ± SD | 8.75 ± 3.77 | 8.65 ± 3.87 | 8.95 ± 3.52 | 8.99 ± 3.57 | 0.679 |
Neu, 109/L, mean ± SD | 6.47 ± 3.79 | 6.47 ± 4.08 | 6.80 ± 3.40 | 6.07 ± 2.60 | 0.483 |
Ly, 109/L, mean ± SD | 1.54 ± 1.15 | 1.49 ± 0.81 | 1.64 ± 2.01 | 1.66 ± 1.11 | 0.327 |
Mn, 109/L, mean ± SD | 0.59 ± 0.54 | 0.61 ± 0.63 | 0.58 ± 0.27 | 0.50 ± 0.16 | 0.27 |
N/M, mean ± SD | 5.80 ± 6.19 | 5.81 ± 6.50 | 6.34 ± 6.30 | 5.08 ± 4.13 | 0.436 |
L/M, mean ± SD | 3.28 ± 3.05 | 3.14 ± 2.65 | 3.42 ± 4.36 | 3.76 ± 2.86 | 0.266 |
Eon, 109/L, mean ± SD | 0.14 ± 0.25 | 0.13 ± 0.18 | 0.16 ± 0.27 | 0.19 ± 0.44 | 0.079 |
TC, mmol/L, mean ± SD | 4.56 ± 1.20 | 4.62 ± 1.17 | 4.52 ± 1.36 | 4.32 ± 1.11 | 0.159 |
TG, mmol/L, mean ± SD | 1.65 ± 1.29 | 1.63 ± 1.29 | 1.90 ± 1.61 | 1.49 ± 0.69 | 0.1 |
HDL, mmol/L, mean ± SD | 1.23 ± 0.46 | 1.24 ± 0.49 | 1.21 ± 0.42 | 1.19 ± 0.38 | 0.606 |
LDL, mmol/L, mean ± SD | 2.78 ± 0.97 | 2.83 ± 0.94 | 2.70 ± 1.10 | 2.62 ± 0.97 | 0.176 |
BUN, mmol/L, mean ± SD | 6.35 ± 3.42 | 6.42 ± 3.62 | 6.34 ± 3.30 | 6.02 ± 2.46 | 0.666 |
Cr, μmol/L, mean ± SD | 80.75 ± 49.30 | 83.96 ± 55.50 | 75.36 ± 33.78 | 71.66 ± 26.41 | 0.081 |
Glu, mmol/L, mean ± SD | 7.88 ± 3.44 | 7.74 ± 3.30 | 8.55 ± 3.88 | 7.74 ± 3.47 | 0.13 |
HbA1c, %, mean ± SD | 7.95 ± 6.31 | 8.19 ± 7.45 | 7.54 ± 2.09 | 7.33 ± 2.60 | 0.46 |
INR, mean ± SD | 1.02 ± 0.15 | 1.01 ± 0.12 | 1.03 ± 0.18 | 1.05 ± 0.19 | 0.198 |
FDPs, μg/mL, mean ± SD | 6.67 ± 12.96 | 7.00 ± 14.23 | 5.51 ± 8.57 | 6.53 ± 10.78 | 0.618 |
D-Dimer, mg/L, mean ± SD | 2.53 ± 5.39 | 2.73 ± 6.03 | 2.29 ± 4.27 | 1.85 ± 2.52 | 0.403 |
NT-proBNP, mean ± SD | 1062.22 ± 2025.72 | 1048.42 ± 2026.11 | 1192.05 ± 2145.51 | 967.99 ± 1885.10 | 0.763 |
TOAST types, n (%) | 0.463 | ||||
LAA | 300 (58.0) | 210 (59.2) | 51 (56.7) | 39 (54.2) | |
CE | 151 (29.2) | 106 (29.9) | 26 (28.9) | 19 (26.4) | |
SVO | 48 (9.3) | 29 (8.2) | 8 (8.9) | 11 (15.3) | |
SOE | 5 (1.0) | 4 (1.1) | 1 (1.1) | 0 (0.0) | |
SUE | 13 (2.5) | 6 (1.7) | 4 (4.4) | 3 (4.2) |