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Table 3 Ultrasound characteristics of AR status in different molecular subtypes

From: Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer

Characteristics

TNBC (n = 18)

Luminal A (n = 36)

Luminal B (n = 23)

HER2 overexpression (n = 27)

AR +  (n = 3)

AR– (n = 15)

p value

AR +  (n = 30)

AR– (n = 6)

p value

AR +  (n = 20)

AR– (n = 3)

p value

AR +  (n = 18)

AR– (n = 9)

p value

Shape

  

1.000

  

0.167

  

0.453

  

1.000

 Regular

0 (0.0%)

1 (6.7%)

 

0 (0.0%)

1 (16.7%)

 

3 (15.0%)

1 (33.3%)

 

2 (11.1%)

1 (11.1%)

 

 Irregular

3 (100.0%)

14 (93.3%)

 

30 (100.0%)

5 (83.3%)

 

17 (85.0%)

2 (66.7%)

 

16 (88.9%)

8 (88.9%)

 

Orientation

  

1.000

  

0.677

  

1.000

  

0.695

 Parallel

2 (66.7%)

12 (80.0%)

 

18 (60.0%)

3 (50.0%)

 

10 (50.0%)

2 (66.7%)

 

10 (55.6%)

4 (44.4%)

 

 Vertical

1 (33.3%)

3 (20.0%)

 

12 (40.0%)

3 (50.0%)

 

10 (50.0%)

1 (33.3%)

 

8 (44.4%)

5 (55.6%)

 

Hyperechoic halo

  

1.000

  

1.000

  

0.538

  

1.000

 Absent

2 (66.7%)

12 (80.0%)

 

16 (53.3%)

3 (50.0%)

 

13 (65.0%)

1 (33.3%)

 

11 (61.1%)

6 (66.7%)

 

 Present

1 (33.3%)

3 (20.0%)

 

14 (46.7%)

3 (50.0%)

 

7 (35.0%)

2 (66.7%)

 

7 (38.9%)

3 (33.3%)

 

Margin

  

0.515

  

0.066

  

/

  

0.333

 Smooth

0 (0.0%)

6 (40.0%)

 

1 (3.3%)

2 (33.3%)

 

0 (0.0%)

0 (0.0%)

 

0 (0.0%)

1 (11.1%)

 

 Unsmooth

3 (100.0%)

9 (60.0%)

 

29 (96.7%)

4 (66.7%)

 

20 (100.0%)

3 (100.0%)

 

18 (100.0%)

8 (88.9%)

 

Posterior acoustic pattern

  

0.167

  

0.643

  

0.253

  

1.000

 No-shadowing

2 (66.7%)

15 (100.0%)

 

20 (66.7%)

5 (83.3%)

 

11 (55.0%)

3 (100.0%)

 

13 (72.2%)

6 (66.7%)

 

Shadowing

1 (33.3%)

0 (0.0%)

 

10 (33.3%)

1 (16.7%)

 

9 (45.0%)

0 (0.0%)

 

5 (27.8%)

3 (33.3%)

 

Calcification

  

1.000

  

0.109

  

1.000

  

1.000

 Absent

1 (33.3%)

7 (46.7%)

 

5 (16.7%)

3 (50.0%)

 

8 (40.0%)

1 (33.3%)

 

4 (22.2%)

2 (22.2%)

 

 Present

2 (66.7%)

8 (53.3%)

 

25 (83.3%)

3 (50.0%)

 

12 (60.0%)

2 (66.7%)

 

14 (77.8%)

7 (77.8%)

 

Echo pattern

  

0.314

  

0.024*

  

1.000

  

0.538

 Hypoechoic

1 (33.3%)

1 (6.7%)

 

2 (6.7%)

3 (50.0%)

 

1 (5.0%)

0 (0.0%)

 

2 (11.1%)

0 (0.0%)

 

 Heterogeneous

2 (66.7%)

14 (93.3%)

 

28 (93.3%)

3 (50.0%)

 

19 (95.0%)

3 (100.0%)

 

16 (88.9%)

9 (100.0%)

 

Adler grade

  

1.000

  

1.000

  

0.229

  

1.000

 0–2

1 (33.3%)

6 (40.0%)

 

15 (50.0%)

3 (50.0%)

 

10 (50.0%)

3 (100.0%)

 

1 (5.6%)

0 (0.0%)

 

 3

2 (66.7%)

9 (60.0%)

 

15 (50.0%)

3 (50.0%)

 

10 (50.0%)

0 (0.0%)

 

17 (94.4%)

9 (100.0%)

 

Elasticity score

  

1.000

  

0.374

  

0.155

  

1.000

 2–3

2 (66.7%)

7 (46.7%)

 

12 (40.0%)

4 (66.7%)

 

4 (20.0%)

2 (66.7%)

 

4 (22.2%)

2 (22.2%)

 

 4–5

1 (33.3%)

8 (53.3%)

 

18 (60.0%)

2 (33.3%)

 

16 (80.0%)

1 (33.3%)

 

14 (77.8%)

7 (77.8%)

 

BI-RADS

  

1.000

  

0.643

  

1.000

  

0.683

 3-4a

1 (33.3%)

3 (20.0%)

 

10 (33.3%)

1 (16.7%)

 

5 (25.0%)

1 (33.3%)

 

9 (50.0%)

3 (33.3%)

 

 4b-5

2 (66.7%)

12 (80.0%)

 

20 (66.7%)

5 (83.3%)

 

15 (75.0%)

2 (66.7%)

 

9 (50.0%)

6 (66.7%)

 
  1. TNBC, triple-negative breast cancer; HER2, human epidermal growth factor receptor 2; AR, androgen receptor; BI-RADS, breast imaging reporting and data system; * indicates p < 0.05