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Table 3 Univariate analysis and multivariate logistic regression analysis of the clinical-laboratory characteristics and Radscore in training cohort

From: Development and external validation of a radiomics model for assessment of HER2 positivity in men and women presenting with gastric cancer

Parameters

Univariate analysis

Multivariate analysis

Statistic

p value

OR (95% CI)

p value

Age

 

0.421

0.674

  

Gender

Male/Female

4.830

0.028*

1.4 (0.9–2.2)

0.122

Location

Cardia/Non-cardia

12.629

 < 0.001*

1.6 (1.0–2.6) a

0.044**

cTNM staging

I + II/III + IV

6.292

0.012*

0.4 (0.3–0.7) a

 < 0.001**

Borrmann type

I + II/III + IV

0.538

0.463

  

Size

 

− 1.494

0.136

  

Thickness

 

0.990

0.323

  

Characteristics of enhancement

Mild or moderate/Obvious

0.513

0.474

  

CEA

Normal/Elevated

14.458

 < 0.001*

2.1 (1.3–3.6)a

0.003**

CA125

Normal/Elevated

2.456

0.117

  

CA199

Normal/Elevated

15.559

 < 0.001*

3.0 (1.7–5.4)a

 < 0.001**

CA724

Normal/Elevated

4.108

0.043*

1.5 (0.8–2.7)

0.172

CA153

Normal/Elevated

3.744

0.053*

1.8 (0.6–5.1)

0.262

Radscore

 

5.333

 < 0.001*

2.1 (1.5–3.0)a

 < 0.001**

  1. Note—OR = odds ratio; CI = confidence interval; cTNM staging = clinical TNM staging; CEA = carcinoembryonic antigen; CA125 = carbohydrate antigen 125; CA199 = carbohydrate antigen 199; CA724 = carbohydrate antigen 724; CA153 = carbohydrate antigen 153; Radscore = radiomics signature; * p < 0.1; ** p < 0.05;
  2. aAdjusted OR (95% CI)