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Fig. 4 | Insights into Imaging

Fig. 4

From: Development and external validation of a radiomics model for assessment of HER2 positivity in men and women presenting with gastric cancer

Fig. 4

63-year-old man with gastric cancer (GC). Arterial phase (a) and venous phase CT image (b) showed that the lesion was located in the cardia of the stomach and had a venous phase CT-based Radscore of 0.277840926. According to the CT images and other data, the patient was diagnosed as stage II in terms of clinical TNM (cTNM) staging. Laboratory examination at initial diagnosis showed that the patient had elevated carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199). Nomogram (c) showed that when points for individual predictors were added based on the “Points” scale in the top row, the total points were 348, and the probability of the patient having HER2-positive GC was 91.2%. Histopathological HE staining (d) and immunohistochemistry (IHC, e) confirmed an IHC 3 + gastric adenocarcinoma, namely HER2-positive GC

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