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Table 2 Frequencies of EOB-MRI features

From: Predicting histologic differentiation of solitary hepatocellular carcinoma up to 5 cm on gadoxetate disodium-enhanced MRI

Variable

Training set (n = 128)

Validation set (n = 54)

WD/MD HCC (n = 98)

PD HCC (n = 30)

p value

WD/MD HCC (n = 42)

PD HCC (n = 12)

p value

LI-RADS v2018 featurea

 Size, cm

2.6 (1.6–3.6)

2.8 (1.7–4.0)

0.200

2.8 (1.8–3.8)

2.4 (1.6–3.2)

0.317

 Nonrim arterial phase hyperenhancement

90 (91.8)

25 (83.3)

0.316

38 (90.5)

11 (91.7)

1.000

 Nonperipheral "washout"

87 (88.8)

26 (86.7)

1.000

8 (19.0)

0 (0.0)

0.239

 Enhancing "capsule"

71 (72.4)

21 (70.0)

0.794

32 (76.2)

9 (75.0)

1.000

 Corona enhancement

24 (24.5)

7 (23.3)

0.897

12 (28.6)

3 (25.0)

1.000

 Fat sparing in solid mass

8 (8.2)

5 (16.7)

0.316

0 (0.0)

1 (8.3)

0.222

 Diffusion restriction

97 (99.0)

30 (100.0)

1.000

42 (100.0)

12 (100.0)

 Mild-moderate T2 hyperintensity

95 (96.9)

30 (100.0)

1.000

41 (97.6)

11 (91.7)

0.398

 Iron sparing in solid mass

24 (24.5)

4 (13.3)

0.196

9 (21.4)

2 (16.7)

1.000

 Transitional phase hypointensity

93 (94.9)

30 (100.0)

0.469

40 (95.2)

12 (100.0)

1.000

 Hepatobiliary phase hypointensity

92 (93.9)

29 (96.7)

0.897

42 (100.0)

12 (100.0)

 Nonenhancing "capsule"

13 (13.3)

2 (6.7)

0.510

7 (16.7)

1 (8.3)

0.798

 Nodule-in-nodule

24 (24.5)

9 (30.0)

0.546

6 (14.3)

2 (16.7)

1.000

 Mosaic architecture

16 (16.3)

6 (20.0)

0.641

4 (9.5)

2 (16.7)

0.862

 Fat in mass, more than adjacent liver

41 (41.8)

14 (46.7)

0.640

23 (54.8)

7 (58.3)

0.826

 Blood products in mass

19 (19.4)

4 (13.3)

0.450

5 (11.9)

3 (25.0)

0.506

 Iron in mass, more than liver

3 (3.1)

1 (3.3)

1.000

0 (0.0)

0 (0.0)

 Marked T2 hyperintensity

2 (2.0)

0 (0.0)

1.000

0 (0.0)

1 (8.3)

0.222

 Hepatobiliary phase isointensity

5 (5.1)

1 (3.3)

1.000

0 (0.0)

0 (0.0)

 Tumor in vein

2 (2.0)

1 (3.3)

0.554

1 (2.4)

0 (0.0)

1.000

 Rim arterial phase hyperenhancement

3 (3.1)

5 (16.7)

0.024*

4 (9.5)

0 (0.0)

0.564

 Peripheral "washout"

1 (1.0)

0 (0.0)

1.000

0 (0.0)

0 (0.0)

 Delayed central enhancement

0 (0.0)

0 (0.0)

1 (2.4)

0 (0.0)

1.000

 Targetoid TP or HBP appearance

1 (1.0)

1 (3.3)

0.415

0 (0.0)

0 (0.0)

 Infiltrative appearance

12 (12.2)

3 (10.0)

0.992

2 (4.8)

0 (0.0)

1.000

 Marked diffusion restriction

32 (32.7)

16 (53.3)

0.041*

13 (31.0)

6 (50.0)

0.381

 Necrosis or severe ischemia

15 (15.3)

2 (6.7)

0.361

6 (14.3)

2 (16.7)

1.000

 LR-M category

3 (3.1)

6 (20.0)

0.006*

3 (7.1)

0 (0.0)

1.000

 LR-TIV category

2 (2.0)

1 (3.3)

0.554

1 (2.4)

0 (0.0)

1.000

 LR-3 category

1 (1.0)

0 (0.0)

1.000

0 (0.0)

0 (0.0)

 LR-4 category

9 (9.2)

2 (6.7)

0.954

3 (7.1)

1 (8.3)

1.000

 LR-5 category

83 (84.7)

21 (70.0)

0.071

35 (83.3)

11 (91.7)

0.798

Other imaging feature

 Liver surface retraction

2 (2.0)

0 (0.0)

1.000

0 (0.0)

1 (8.3)

0.222

 Adjacent biliary dilatation

1 (1.0)

1 (3.3)

0.415

0 (0.0)

1 (8.3)

0.222

 Radiologic cirrhosis

60 (61.2)

19 (63.3)

0.835

24 (57.1)

6 (50.0)

0.661

 Bilobar involvement

4 (4.1)

3 (10.0)

0.430

4 (9.5)

0 (0.0)

0.564

 Internal artery

13 (13.3)

3 (10.0)

0.875

5 (11.9)

1 (8.3)

1.000

 Non-smooth tumor margin

49 (50.0)

17 (56.7)

0.523

21 (50.0)

4 (33.3)

0.307

 Peritumoral hypointensity on PVP

18 (18.4)

4 (13.3)

0.523

3 (7.1)

2 (16.7)

0.661

 Peritumoral hypointensity on TP

16 (16.3)

3 (10.0)

0.576

3 (7.1)

2 (16.7)

0.661

 Peritumoral hypointensity on HBP

25 (25.5)

11 (36.7)

0.234

7 (16.7)

1 (8.3)

0.798

 Marked HBP hypointensity

12 (12.2)

19 (63.3)

 < 0.001*

4 (9.5)

8 (66.7)

 < 0.001*

 Single nodular type growth

71 (72.4)

19 (63.3)

0.339

15 (35.7)

4 (33.3)

1.000

 Peritumoral hyperintensity on T2WI

7 (7.1)

5 (16.7)

0.227

2 (4.8)

0 (0.0)

1.000

 Non-hypervascular HBP hypointense

 Nodules

19 (19.4)

8 (26.7)

0.393

17 (40.5)

4 (33.3)

0.911

  1. Data are expressed as the frequencies of MRI features, with percentages in parentheses
  2. EOB-MRI, gadoxetic acid–enhanced magnetic resonance imaging; LI-RADS/LR, Liver Imaging Reporting and Data System; HCC, hepatocellular carcinoma; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; HBV; T2WI, T2-weighted imaging; PVP, portal venous phase; TP, transitional phase; HBP, hepatobiliary phase
  3. *Variables are statistically significant
  4. aLI-RADS v2018 features correlated with growth or ultrasound visibility were not assessed due to lack of prior and concurrent ultrasound examinations