Variable | Training set (n = 128) | Validation set (n = 54) | ||||
---|---|---|---|---|---|---|
WD/MD HCC (n = 98) | PD HCC (n = 30) | p value | WD/MD HCC (n = 42) | PD HCC (n = 12) | p value | |
LI-RADS v2018 featurea | ||||||
Size, cm | 2.6 (1.6–3.6) | 2.8 (1.7–4.0) | 0.200 | 2.8 (1.8–3.8) | 2.4 (1.6–3.2) | 0.317 |
Nonrim arterial phase hyperenhancement | 90 (91.8) | 25 (83.3) | 0.316 | 38 (90.5) | 11 (91.7) | 1.000 |
Nonperipheral "washout" | 87 (88.8) | 26 (86.7) | 1.000 | 8 (19.0) | 0 (0.0) | 0.239 |
Enhancing "capsule" | 71 (72.4) | 21 (70.0) | 0.794 | 32 (76.2) | 9 (75.0) | 1.000 |
Corona enhancement | 24 (24.5) | 7 (23.3) | 0.897 | 12 (28.6) | 3 (25.0) | 1.000 |
Fat sparing in solid mass | 8 (8.2) | 5 (16.7) | 0.316 | 0 (0.0) | 1 (8.3) | 0.222 |
Diffusion restriction | 97 (99.0) | 30 (100.0) | 1.000 | 42 (100.0) | 12 (100.0) | – |
Mild-moderate T2 hyperintensity | 95 (96.9) | 30 (100.0) | 1.000 | 41 (97.6) | 11 (91.7) | 0.398 |
Iron sparing in solid mass | 24 (24.5) | 4 (13.3) | 0.196 | 9 (21.4) | 2 (16.7) | 1.000 |
Transitional phase hypointensity | 93 (94.9) | 30 (100.0) | 0.469 | 40 (95.2) | 12 (100.0) | 1.000 |
Hepatobiliary phase hypointensity | 92 (93.9) | 29 (96.7) | 0.897 | 42 (100.0) | 12 (100.0) | – |
Nonenhancing "capsule" | 13 (13.3) | 2 (6.7) | 0.510 | 7 (16.7) | 1 (8.3) | 0.798 |
Nodule-in-nodule | 24 (24.5) | 9 (30.0) | 0.546 | 6 (14.3) | 2 (16.7) | 1.000 |
Mosaic architecture | 16 (16.3) | 6 (20.0) | 0.641 | 4 (9.5) | 2 (16.7) | 0.862 |
Fat in mass, more than adjacent liver | 41 (41.8) | 14 (46.7) | 0.640 | 23 (54.8) | 7 (58.3) | 0.826 |
Blood products in mass | 19 (19.4) | 4 (13.3) | 0.450 | 5 (11.9) | 3 (25.0) | 0.506 |
Iron in mass, more than liver | 3 (3.1) | 1 (3.3) | 1.000 | 0 (0.0) | 0 (0.0) | – |
Marked T2 hyperintensity | 2 (2.0) | 0 (0.0) | 1.000 | 0 (0.0) | 1 (8.3) | 0.222 |
Hepatobiliary phase isointensity | 5 (5.1) | 1 (3.3) | 1.000 | 0 (0.0) | 0 (0.0) | – |
Tumor in vein | 2 (2.0) | 1 (3.3) | 0.554 | 1 (2.4) | 0 (0.0) | 1.000 |
Rim arterial phase hyperenhancement | 3 (3.1) | 5 (16.7) | 0.024* | 4 (9.5) | 0 (0.0) | 0.564 |
Peripheral "washout" | 1 (1.0) | 0 (0.0) | 1.000 | 0 (0.0) | 0 (0.0) | – |
Delayed central enhancement | 0 (0.0) | 0 (0.0) | – | 1 (2.4) | 0 (0.0) | 1.000 |
Targetoid TP or HBP appearance | 1 (1.0) | 1 (3.3) | 0.415 | 0 (0.0) | 0 (0.0) | – |
Infiltrative appearance | 12 (12.2) | 3 (10.0) | 0.992 | 2 (4.8) | 0 (0.0) | 1.000 |
Marked diffusion restriction | 32 (32.7) | 16 (53.3) | 0.041* | 13 (31.0) | 6 (50.0) | 0.381 |
Necrosis or severe ischemia | 15 (15.3) | 2 (6.7) | 0.361 | 6 (14.3) | 2 (16.7) | 1.000 |
LR-M category | 3 (3.1) | 6 (20.0) | 0.006* | 3 (7.1) | 0 (0.0) | 1.000 |
LR-TIV category | 2 (2.0) | 1 (3.3) | 0.554 | 1 (2.4) | 0 (0.0) | 1.000 |
LR-3 category | 1 (1.0) | 0 (0.0) | 1.000 | 0 (0.0) | 0 (0.0) | – |
LR-4 category | 9 (9.2) | 2 (6.7) | 0.954 | 3 (7.1) | 1 (8.3) | 1.000 |
LR-5 category | 83 (84.7) | 21 (70.0) | 0.071 | 35 (83.3) | 11 (91.7) | 0.798 |
Other imaging feature | ||||||
Liver surface retraction | 2 (2.0) | 0 (0.0) | 1.000 | 0 (0.0) | 1 (8.3) | 0.222 |
Adjacent biliary dilatation | 1 (1.0) | 1 (3.3) | 0.415 | 0 (0.0) | 1 (8.3) | 0.222 |
Radiologic cirrhosis | 60 (61.2) | 19 (63.3) | 0.835 | 24 (57.1) | 6 (50.0) | 0.661 |
Bilobar involvement | 4 (4.1) | 3 (10.0) | 0.430 | 4 (9.5) | 0 (0.0) | 0.564 |
Internal artery | 13 (13.3) | 3 (10.0) | 0.875 | 5 (11.9) | 1 (8.3) | 1.000 |
Non-smooth tumor margin | 49 (50.0) | 17 (56.7) | 0.523 | 21 (50.0) | 4 (33.3) | 0.307 |
Peritumoral hypointensity on PVP | 18 (18.4) | 4 (13.3) | 0.523 | 3 (7.1) | 2 (16.7) | 0.661 |
Peritumoral hypointensity on TP | 16 (16.3) | 3 (10.0) | 0.576 | 3 (7.1) | 2 (16.7) | 0.661 |
Peritumoral hypointensity on HBP | 25 (25.5) | 11 (36.7) | 0.234 | 7 (16.7) | 1 (8.3) | 0.798 |
Marked HBP hypointensity | 12 (12.2) | 19 (63.3) | < 0.001* | 4 (9.5) | 8 (66.7) | < 0.001* |
Single nodular type growth | 71 (72.4) | 19 (63.3) | 0.339 | 15 (35.7) | 4 (33.3) | 1.000 |
Peritumoral hyperintensity on T2WI | 7 (7.1) | 5 (16.7) | 0.227 | 2 (4.8) | 0 (0.0) | 1.000 |
Non-hypervascular HBP hypointense | ||||||
Nodules | 19 (19.4) | 8 (26.7) | 0.393 | 17 (40.5) | 4 (33.3) | 0.911 |