Table 4 Percentage difference of mean ADC when measuring with the same strategy on a slice two steps down in the caudal direction. The measured mean ADC can drastically vary between nearby slices if the tumor is heterogeneous. No measurements were done with the solid strategy on patients 2 and 5, as these did not have any necrotic, cystic, or hemorrhagic components. All methods yield significantly different distributions as determined by the two-sample Kolmogorov–Smirnov test

From: Methodological considerations on segmenting rhabdomyosarcoma with diffusion-weighted imaging—What can we do better?