Methodological considerations on segmenting rhabdomyosarcoma with diffusion-weighted imaging—What can we do better?

Insights into Imaging

Table 3 Percent difference of the mean apparent diffusion coefficient (ADC) averaged over all patients between every pair of strategies described in Methods

Method	Whole tumor (%)	Inside (%)	Solid (%)	Inside solid (%)	Circle (%)	Max DWI circles (%)
Whole tumor		0.50	− 5.58	− 5.82	0.73	− 21.66
Inside	− 0.50		− 6.05	− 6.30	0.23	− 22.05
Solid	5.91	6.44		− 0.26	6.68	− 17.03
Inside solid	6.18	6.72	0.26		6.96	− 16.81
Circle	− 0.73	− 0.23	− 6.27	− 6.51		− 22.23
Max DWI circles	27.65	28.29	20.53	20.21	28.58

Bold numbers indicate significantly different distributions as determined by the two-sample Kolmogorov–Smirnov test. Excluding the edge from an ROI yields no significant differences in the distribution. All other methods do yield different distributions