Fig. 4

Normalized histograms of the apparent diffusion coefficient (ADC) of different regions of interest (ROIs) acquired with the strategies described in Methods. Varying segmentation methods can yield different distributions of the measured diffusion. Including necrotic, cystic, or hemorrhagic regions can result in non-Gaussian distributions. Patients 2 and 5 did not show any necrotic, cystic, or hemorrhagic tumor components and as such, specific ROIs that exclude these have not been drawn