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Insights into Imaging

Table 1 Overview of the included ADC studies and demographics of the included patients

From: Diffusion imaging could aid to differentiate between glioma progression and treatment-related abnormalities: a meta-analysis

Author

Total (n)

Mean age (SD/range)

Sex (M/F)

WHO grade (n)

b-values (s/mm2)

TP

Mean ADC value (SD)

95% CI

PsP

Mean ADC (SD);

95%-CI

TP

FP

FN

TN

Sensitivity/ Specificity (%/%)

(n; lesions)

Enhancing lesion (× 10–3 mm2/s)

(n; lesions)

Enhancing lesion (× 10–3 mm–2/s)

Zeng et al. [15]

55

43.67 (11.9) years

30/25

3 (36)

b0/1000

32

1.20 (0.80)

0.92–1.48

23

1.39 (0.90)

1.02–1.76

NR

NR

NR

NR

NR

4 (19)

Xu et al. [16]

35

45.2 (21–65) years

19/16

2 (4)

b0/1000

20

1.23 (0.20)

1.14–1.32

15

1.54 (0.17)

1.45–1.63

17

2

3

13

85/87

3 (14)

4 (17)

Lee et al. [17]

22

48.5 (15.8)

14-Aug

3 (3)

b0/1000

10

1.22 (0.39)

0.98–1.45

12

1.35 (0.17)

1.24–1.45

8

2

2

10

80/83

4 (19)

Chu et al. [22]

30

50.8 (25–72)

16/14

4 (30)

b0/1000/

15

1.27 (0.10)

1.07–1.46

15

1.33 (0.06)

1.30–1.36

14

1

0

15

100/94

3000

12 unmethylated;

 

18 methylated

 

Song et al. (2013)

20

57.1 (8.3); 44.4 (15.1)

10-Oct

4 (20)

b0/1000

10

1.27 (0.2)

1.18–1.44

10

1.44 (0.18)

1.36–1.52

9

1

1

9

90/90

7 unmethylated; 13 methylated

Prager et al. [19]

68

54.9 (22.6–79.4) years

51/17

3 (13)

b0/1000

58

1.38 (0.13)

1.35–1.41

10

1.59 (0.19)

1.47–1.71

41

2

3

5

93/71

4 (55)

19 unmethylated; 12 methylated

Kazda et al. [20]

39

51 (29–66)

28-Nov

4 (39)

b0/1000

29

0.61 (0.04)

0.59–0.63

10

1.33 (0.4)

1.08–1.58

28

1

0

10

100/91

Zakhari et al. [21]

17

55.9 (10.3) years

13-Apr

HGG

b0/1000

9

1.10 (0.21)

0.96–1.24

8

1.06 (0.27)

0.87–1.25

7

3

2

5

78/63

Yang et al. [11]

91

48.7 (14.2)(9–77) years

53/38

3 (29)

b0/1000

51

0.80 (0.08)

0.78–0.82

40

1.3 (0.05)

1.28–1.32

40

7

11

33

78/83

4 (62)

22 IDHm; 69 IDHwt

Park et al. [12]

36

52.3 (13.7)(n = 25) 57.1 (14.8)(n = 11)

18/18

2 (3)

b0/1000

25

1.28 (0.14)

1.23–1.33

11

1.47 (0.21)

1.35–1.59

21

4

4

7

84/64

3 (6)

4 (27)

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