Fig. 8

CNO in an 8-year-old girl complaining of hip and leg pain. Whole-body MRI (a–d) depicted multifocal bone lesions at the distal metaphysis of both femurs (a–c), distal metaphysis of the left tibia (b) and right fibula (c), right calcaneus (d), left acetabulum (c), left metacarpal bone head (a) and bone marrow edema at a mid-thoracic vertebral body (a). The vertebral lesion was asymptomatic and its detection in a preclinical scenario may change the treatment approach and prevent complications