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Table 3 Comparison between sickle cell disease patients who had serum ferritin ≤ and > 2500 ug/L

From: The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

Variable

Serum ferritin ≤ 2500 ug/L (n = 33)

Serum ferritin > 2500 ug/L (n = 33)

p value

Age (years); mean ± SD

14.78 ± 6.85

16.55 ± 7.18

0.315

Males; n (%)

15 (46.9)

19 (57.6)

0.388

Iron Overload (mg/kg/day); mean ± SD

0.17 ± 0.14

0.28 ± 0.13

0.001

On chelation; n (%)

20 (62.5)

32 (97.0)

0.001

Poor compliance to chelation; n (%)

6 (31.6)

15 (50.0)

0.204

Pre-transfusion hemoglobin (g/dL); mean ± SD

7.66 ± 1.46

8.37 ± 1.30

0.046

HbS (%); mean ± SD

63.28 ± 16.04

59.57 ± 24.29

0.504

HbF (%); median (IQR)

6.2 (0.8–12.2)

3.6 (1.3–10)

0.579

Lactate dehydrogenase (IU/L); mean ± SD

547.38 ± 331.71

525.21 ± 204.67

0.749

Total bilirubin (mg/dL); mean ± SD

2.59 ± 1.50

2.60 ± 1.09

0.970

Indirect bilirubin (mg/dL)

1.33 (0.9–2.18)

1.8 (0.9–2.12)

0.549

Serum amylase; mean ± SD

57.41 ± 24.46

56.12 ± 18.74

0.815

LIC (mg/g liver dry weight); median (IQR)

6.19 (3.06–11.02)

16.16 (12.94–24.7)

0.000

Normal; n (%)

7 (21.9)

0 (0.0)

0.000

Mild; n (%)

13 (40.6)

2 (6.1)

 

Moderate; n (%)

10 (31.3)

14 (42.4)

 

Severe; n (%)

2 (6.3)

17 (51.5)

 

Cardiac T2* (msec); mean ± SD

32.03 ± 5.09

30.79 ± 7.80

0.454

Pancreatic MRI (msec); median (IQR)

52.85 (35.35 – 83.5)

54.9 (31.8 – 87)

0.847