Variable | Normal pancreatic MRI (n = 14) | Abnormal* pancreatic MRI (n = 9) | p value |
---|---|---|---|
Age (years); mean ± SD | 17.79 ± 8.80 | 20.11 ± 8.80 | 0.543 |
Males; n (%) | 8 (57.1) | 3 (33.3) | 0.265 |
Transfusion index (mL/kg/year); median (IQR) | 240 (120–240) | 120 (60–240) | 0.158 |
Iron Overload (mg/kg/day); mean ± SD | 0.30 ± 0.14 | 0.22 ± 0.17 | 0.226 |
On chelation; n (%) | 11 (78.6) | 7 (77.8) | 0.964 |
Poor compliance to chelation; n (%) | 5 (45.5) | 5 (71.4) | 0.280 |
Pre-transfusion hemoglobin (g/dL); mean ± SD | 8.74 ± 1.64 | 6.61 ± 0.54 | 0.004 |
HbS (%); mean ± SD | 67.79 ± 24.72 | 54.92 ± 25.69 | 0.312 |
HbF (%); median (IQR) | 0 (0–8.2) | 3.45 (3.1–12.2) | 0.177 |
Lactate dehydrogenase (IU/L); mean ± SD | 472.14 ± 155.57 | 768.38 ± 531.13 | 0.062 |
Total bilirubin (mg/dL); mean ± SD | 2.42 ± 1.16 | 4.05 ± 1.59 | 0.012 |
Indirect bilirubin (mg/dL) | 1.515 (0.96–2.1) | 2.04 (1.89–2.71) | 0.048 |
Serum amylase; mean ± SD | 62.43 ± 24.15 | 70.00 ± 32.37 | 0.539 |
Serum ferritin (ug/L); median (IQR) | 3670.5 (1456–4743) | 1987 (1650–4313) | 0.571 |
Serum ferritin level > 2500; n (%) | 8 (57.1) | 4 (44.4) | 0.552 |
LIC (mg/g liver dry weight); median (IQR) | 14.045 (7.35–20.83) | 14.03 (9.2–24.89) | 0.614 |
Normal; n (%) | 1 (7.1) | 0 (0.0) | 0.859 |
Mild; n (%) | 3 (21.4) | 2 (22.2) | |
Moderate; n (%) | 5 (35.7) | 3 (33.3) | |
Severe; n (%) | 5 (35.7) | 4 (44.4) | |
Cardiac T2* (msec); mean ± SD | 31.51 ± 4.90 | 29.99 ± 3.87 | 0.442 |