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Table 2 Comparison between sickle cell disease patients with normal and those with abnormal pancreatic MRI

From: The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

Variable

Normal pancreatic MRI (n = 14)

Abnormal* pancreatic MRI (n = 9)

p value

Age (years); mean ± SD

17.79 ± 8.80

20.11 ± 8.80

0.543

Males; n (%)

8 (57.1)

3 (33.3)

0.265

Transfusion index (mL/kg/year); median (IQR)

240 (120–240)

120 (60–240)

0.158

Iron Overload (mg/kg/day); mean ± SD

0.30 ± 0.14

0.22 ± 0.17

0.226

On chelation; n (%)

11 (78.6)

7 (77.8)

0.964

Poor compliance to chelation; n (%)

5 (45.5)

5 (71.4)

0.280

Pre-transfusion hemoglobin (g/dL); mean ± SD

8.74 ± 1.64

6.61 ± 0.54

0.004

HbS (%); mean ± SD

67.79 ± 24.72

54.92 ± 25.69

0.312

HbF (%); median (IQR)

0 (0–8.2)

3.45 (3.1–12.2)

0.177

Lactate dehydrogenase (IU/L); mean ± SD

472.14 ± 155.57

768.38 ± 531.13

0.062

Total bilirubin (mg/dL); mean ± SD

2.42 ± 1.16

4.05 ± 1.59

0.012

Indirect bilirubin (mg/dL)

1.515 (0.96–2.1)

2.04 (1.89–2.71)

0.048

Serum amylase; mean ± SD

62.43 ± 24.15

70.00 ± 32.37

0.539

Serum ferritin (ug/L); median (IQR)

3670.5 (1456–4743)

1987 (1650–4313)

0.571

Serum ferritin level > 2500; n (%)

8 (57.1)

4 (44.4)

0.552

LIC (mg/g liver dry weight); median (IQR)

14.045 (7.35–20.83)

14.03 (9.2–24.89)

0.614

Normal; n (%)

1 (7.1)

0 (0.0)

0.859

Mild; n (%)

3 (21.4)

2 (22.2)

 

Moderate; n (%)

5 (35.7)

3 (33.3)

 

Severe; n (%)

5 (35.7)

4 (44.4)

 

Cardiac T2* (msec); mean ± SD

31.51 ± 4.90

29.99 ± 3.87

0.442

  1. *Patients with Abnormal* pancreatic MRI include those with pancreatic MRI > 100 Hz