Table 1 Clinical characteristics of training and validation sets
Cohort | Training set (n = 309) | Internal validation set (n = 78) | External validation set (n = 30) | p value |
|---|---|---|---|---|
Age (years) | 45.49 ± 16.06 | 46.94 ± 17.46 | 44.70 ± 19.17 | 0.740 |
Menopausal status | 0.581 | |||
Postmenopausal | 154 (49.8) | 39 (50.0) | 12 (40.0) | |
Premenopausal | 155 (50.2) | 39 (50.0) | 18 (60.0) | |
Parity | 0.219 | |||
Multipara | 256 (82.8) | 64 (82.1) | 21 (70.0) | |
Nullipara | 53 (17.2) | 14 (17.9) | 9 (30.0) | |
Abdominal symptoms | 0.362 | |||
Pain and distention | 135 (43.7) | 37 (47.4) | 17 (56.7) | |
None | 174 (56.3) | 41 (52.6) | 13 (43.3) | |
CA125 (U/mL) | 0.118 | |||
> 35 | 78 (25.2) | 14 (17.9) | 11 (36.7) | |
≥ 35 | 231 (74.8) | 64 (82.1) | 19 (63.3) | |
HE4a (pmol/L) | 1.000 | |||
Abnormal | 20 (6.5) | 5 (6.4) | 2 (6.7) | |
Normal | 289 (93.5) | 73 (93.6) | 28 (93.3) | |
Final diagnosis | 0.549 | |||
Benign | 224 (72.5) | 57 (73.1) | 19 (63.3) | |
Borderline | 85 (27.5) | 21 (26.9) | 11 (36.7) | |
Histopathology | 0.080 | |||
Serous | 148 (47.9) | 40 (51.3) | 21 (70.0) | |
Mucinous | 141 (45.6) | 33 (42.3) | 6 (20.0) | |
Others | 20 (6.5) | 5 (6.4) | 3 (10.0) |