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Table 3 Diagnostic performance of PET/MRI and PET/CT for a score ≥ 3 calculated per patient, per examination and per lesion. 95%CI were calculated using the Clopper–Pearson method

From: Detection of distant metastases and distant second primary cancers in head and neck squamous cell carcinoma: comparison of [18F]FDG PET/MRI and [18F]FDG PET/CT

 

Analysis per patient

(n = 82)

Analysis per examination

(n = 103)

Analysis per lesion

(n = 183)

PET/MRI

PET/CT

PET/MRI

PET/CT

PET/MRI

PET/CT

Sensitivity (%)

94 [70–100]

94 [70–100]

96 [78–100]

96 [78–100]

95 [88–99]

90 [81–95]

Specificity (%)

88 [77–95]

91 [81–97]

90 [81–96]

93 [84–97]

85 [77–91]

86 [78–92]

Accuracy (%)

89 [80–95]

91 [83–96]

91 [84–96]

93 [86–97]

90 [84–94]

88 [82–92]

PPV (%)

65 [49–78]

71 [53–84]

73 [54–88]

79 [59–92]

84 [75–91]

83 [73–90]

NPV (%)

98 [90–100]

98 [90–100]

99 [93–100]

99 [93–100]

96 [89–99]

92 [84–96]

Positive likelihood ratio

7.73 [3.99–14.99]

10.31 [4.76–22.35]

9.57 [4.93–18.57]

12.75 [5.88–27.67]

6.40 [4.00–10.24]

6.46 [3.95–10.57]

Negative likelihood ratio

0.07 [0.01–0.48]

0.07 [0.01–0.46]

0.05 [0.01–0.33]

0.05 [0.01–0.32]

0.06 [0.02–0.15]

0.12 [0.06–0.23]

  1. The McNemar test was used for comparisons (sensitivity, specificity, accuracy). There were no statistically significant differences between PET/MRI and PET/CT (p values varied between 0.134 and 1)
  2. PPV, positive predictive value; NPV, negative predictive value