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Fig. 5 | Insights into Imaging

Fig. 5

From: Detection of distant metastases and distant second primary cancers in head and neck squamous cell carcinoma: comparison of [18F]FDG PET/MRI and [18F]FDG PET/CT

Fig. 5

False-negative PET/MRI (A) and PET/CT (B) in an 89-year-old male with primary SCC of the oral cavity. Both PET/MRI and PET/CT were rated as negative for distant metastases or second primary cancers (diagnostic score = 1). PET/MRI image (A) shows no lesion. PET/CT (B) and detail of the corresponding CT component of the PET/CT (C) show a non-[18F]FDG-avid 5 mm solid lung nodule (arrow in C), which was considered as benign according to diagnostic criteria (no [18F]FDG uptake and < 8 mm in size). The lesion was rated with a score of 1 on PET/MRI and PET/CT. Follow-up CT obtained two months later (D) showed no change in size and shape of the 5 mm nodule (arrow). CT obtained 7 months later (E) revealed no change in the 5 mm nodule (arrow), however, a pleural metastasis (dashed arrow) that was confirmed histologically. As the pleural metastasis occurred within the 2-year follow-up, both PET/CT and PET/MRI were considered as false negative

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