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Insights into Imaging

Table 3 Comparison of T2 and ADC values between good responders and non-good responders and the correlation test

From: T2 relaxation time for the early prediction of treatment response to chemoradiation in locally advanced rectal cancer

 

TRG 1–2 (median, interquartile distance)

TRG 3–5 (median, interquartile distance)

Mann–Whitney U (Z, P)

Rank correlation with TRG (r, P)

Vpre (cc)

18.3 (11.2)

16.3 (10.9)

 − 0.765, 0.445

 − 0.202, 0.206

Vduring (cc)

10.0 (5.7)

10.2 (6.5)

0.652, 0.514

 − 0.003, 0.983

Vpost (cc)

6.0 (2.8)

7.8 (6.0)

3.134, 0.002*

0.404, 0.008*

ΔVduring (%)

45.9 (15.6)

26.8 (21.0)

3.234. 0.001*

 − 0.485, 0.001*

ADCpre (× 10−3 mm2/s)

1.21 (0.71)

1.24 (0.65)

 − 1.601, 0.109

0.283, 0.073

ADCduring (× 10−3 mm2/s)

1.34 (0.21)

1.36 (0.56)

 − 0.384, 0.701

0.026, 0.873

ΔADCduring (%)

25 (32)

10 (19)

 − 2.914, 0.004*

0.485, 0.001*

T2pre (ms)

71.0 (5.0)

68.5 (13.0)

 − 0.929, 0.350

 − 0.108, 0.500

T2during (ms)

61.0 (5.0)

65.5 (9.0)

 − 2.800, 0.005*

0.586, < 0.001*

T2post (ms)

53.0 (6.0)

61.0 (8.0)

4.390, < 0.001*

0.857, < 0.001*

ΔT2during (%)

13.9 (9.3)

4.5 (8.5)

 − 4.474, < 0.001*

 − 0.753, < 0.001*

  1. *p < 0.05
  2. Vpre: tumor volume at pre-treatment MRI; Vduring: tumor volume during CRT; Vpost: tumor volume after CRT; ΔVduring: the relative early tumor volume decreased from beginning to the middle of CRT; ADCpre: ADC values at pre-treatment MRI; ADCduring: ADC values of MRI during CRT; ΔADCduring: the relative early ADC increase from beginning to middle of CRT; T2pre: T2 relaxation time at pre-treatment MRI; T2during: T2 relaxation time of MRI during CRT; T2post: T2 relaxation time of MRI after CRT; ΔT2during: the relative T2 increase from initiation to the end of radiotherapy
  3. Cc, cubic centimeter; ms, millisecond
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