Fig. 2
From: Renal functional and interstitial fibrotic assessment with non-Gaussian diffusion kurtosis imaging
Example of DKI metrics pseudocolor maps and pathological images in a 29-year-old female nephritis syndrome patient with normal renal function (eGFR: 122.1 ml/min/1.73 m2) and a 37-year-old male hypertension patient with renal insufficiency (eGFR: 20.3 ml/min/1.73 m2). Increased cortical MK and parenchymal Ka and decreased parenchymal MD and medullary FA were determined in patient 2 compared with patient 1. The renal pathology (Immunofluorescence of IgA, Haematoxylin–Eosin, Periodic Acid–Silver Methenamine and Masson’s Trichrome stain; magnification, × 400) results indicated mild mesangial hyperplasia IgA nephropathy with glomerulosclerosis, tubular atrophy or interstitial fibrosis < 25% in patient 1 and chronic thrombotic microangiopathy with glomerulosclerosis, tubular atrophy and interstitial fibrosis > 50% in patient 2