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Table 4 Results of univariate and multivariate analyses of overall survival

From: Recurrence dynamics after curative surgery in patients with invasive mucinous adenocarcinoma of the lung

Variable

Univariate

Multivariate

HR

95% CI

p value

HR

95% CI

p value

Clinical factor

 Sex, female

0.647

0.319

1.314

0.228

    

 Age (years), older

1.086

1.045

1.127

 < 0.001

1.110

1.040

1.185

0.002

 Smoking, present

1.977

0.974

4.012

0.059

12.893

3.226

51.532

 < 0.001

 Surgical procedure, lobectomy

–

0.000

Inf

0.997

    

 Adjuvant treatment, present

1.410

0.649

3.064

0.385

    

 Recurrence subtype, poly*

6.872

1.996

23.660

0.002

    

CT factor

   

 CT morphology, consolidative type

3.181

1.571

6.442

0.001

6.779

1.675

27.444

0.007

 Solidity, part-solid type

1.196

0.591

2.420

0.618

    

 Well-defined heterogenous GGO

2.341

1.006

5.444

0.048

1.793

0.473

6.797

0.391

 Lobulated margin

1.068

0.523

2.180

0.857

    

 Spiculated margin

0.716

0.320

1.602

0.417

    

 CT air-bronchogram

1.010

0.495

2.062

0.978

    

 CT angiogram sign, present

1.049

0.403

2.732

0.922

    

Pathologic factor

   

 Surgical bronchial margin, ≤ 1 cm

3.147

1.185

8.358

0.021

2.699

0.431

16.901

0.289

 T stage, higher, T2/3 vs. T1

6.242

2.183

17.850

0.001

13.005

2.057

82.213

0.006

 N stage, higher, N2 vs. N0†

7.097

2.959

17.020

 < 0.001

7.653

1.927

30.386

0.004

 Tumor differentiation, poor, poor vs. well‡

5.414

2.006

14.612

0.001

5.071

0.697

36.924

0.109

 Aerogenous spread, present

1.018

0.490

2.116

0.962

    

 Mucin, present

0.458

0.218

0.963

0.039

1.576

0.460

5.404

0.469

 STAS, present

2.501

0.864

7.239

0.091

7.463

1.702

32.729

0.008

 EGFR mutation, yes

0.944

0.326

2.730

0.915

    
  1. Bold numbers indicate statistical significance (p < 0.10 on univariate analysis and p < 0.05 on multivariate analysis). HR hazard ratio, CI confidence interval, CT computed tomography, STAS spread through air spaces, EGFR epidermal growth factor receptor
  2. *Multivariate analysis could not be performed due to missing data; †’N0’ was regarded as reference; ‡’Well differentiation’ was regarded as reference