Recurrence dynamics after curative surgery in patients with invasive mucinous adenocarcinoma of the lung

Insights into Imaging

Table 3 Results of univariate and multivariate analyses of disease-free survival

Variable	Univariate				Multivariate
Variable	HR	95% CI		p value	HR	95% CI		p value
Clinical factor
Sex, female	1.088	0.557	2.125	0.806
Age (years), older	1.039	1.007	1.072	0.017	1.026	0.986	1.067	0.204
Smoking, present	1.221	0.607	2.456	0.575
Surgical procedure, lobectomy	–	0.000	Inf	0.997
Adjuvant treatment, present	1.870	0.930	3.760	0.079	1.293	0.554	3.017	0.552
CT factor
CT morphology, consolidative type	3.404	1.747	6.632	< 0.001	3.556	1.395	9.063	0.008
Solidity, part-solid type	1.163	0.599	2.257	0.655
Well-defined heterogenous GGO	2.604	1.181	5.743	0.018	1.058	0.362	3.097	0.918
Lobulated margin	1.472	0.758	2.856	0.253
Spiculated margin	1.114	0.554	2.239	0.763
CT air bronchogram	0.964	0.494	1.884	0.916
CT angiogram sign, present	0.861	0.334	2.220	0.757
Pathologic factor
Surgical bronchial margin, ≤ 1 cm	2.956	1.132	7.720	0.027	1.145	0.358	3.662	0.819
T stage, higher	6.329	2.451	16.343	< 0.001	4.102	1.151	14.627	0.030
N stage, higher, N2 vs. N0^*	7.332	3.241	16.586	< 0.001	7.295	2.523	21.092	< 0.001
Tumor differentiation, poor, poor vs. well^†	2.768	0.823	9.306	0.100
Aerogenous spread, present	1.523	0.749	3.096	0.245
Mucin, present	0.513	0.259	1.016	0.056	0.616	0.257	1.475	0.276
STAS, present	1.469	0.635	3.399	0.368
EGFR mutation, yes	1.116	0.458	2.716	0.809

Bold numbers indicate statistical significance (p < 0.10 on univariate analysis and p < 0.05 on multivariate analysis). HR hazard ratio, CI confidence interval, CT computed tomography, STAS spread through air spaces, EGFR epidermal growth factor receptor
^*’N0’ was regarded as reference
^†’Well differentiated’ was regarded as reference