Study | Sample size | Strength of MRI system | Sequence used | TR | TE |
---|---|---|---|---|---|
Au et al. [125] | 13 Patients with early stage AD, 10 patients with late stage AD, and 30 healthy subjects | 3 T | 3D fast-field echo | 45 ms | 8echoes/ΔTE:5.2 ms/TE1:4.0 ms |
Syam et al. [136] | 26 Patients with PD, 27 patients with PSP, and 26 healthy subjects | 3 T | 3D multi-echo gradient-echo | 62.2 ms | 5 echoes/range 5.7–29.5 ms |
Li et al. [132] | 114 Healthy subjects | 3Â T | Gradient echo imaging | 53Â ms | 40Â ms |
 | 336 Healthy subjects | 3 T |  | 25 ms | 17.5 ms |
 | 173 Healthy subjects | 1.5 T |  | 25 ms | 17.5 ms |
Cogswell et al. [126] | 296 Healthy subjects, 69 patients with MCI, and 56 patients with amnestic dementia | 3Â T | 3D-MEGRE | 28Â ms | 6.7, 10.6, 14.5,18.4, and 22.4Â ms |
Fedeli et al. [127] | 26 Patients with primary atypical parkinsonisms, and 49 patients with PD | 3Â T | 3D spoiled multi-echo GRE sequences | 36Â ms | 5, 12, 19, 26, and 33Â ms |
Shahmaei et al. [124] | 30 Patients with PD and 15 healthy subjects | 3Â T | GRE T2* | 38Â ms | 4 and 41.8Â ms |
Li et al. [122] | 22 Patients with AD, 22 Patients with MCI, 25 Patients with SCD, and 25 healthy subjects | 3 T | 3D multi-echo gradient-echo | 41.8 ms | 16 echoes/ΔTE: 2.3 ms/TE1: 3.3 ms |
Pu et al. [134] | 16 Healthy adult macaques | 3 T | 3D multi-echo gradient-echo | 60 ms | 32 echoes/ΔTE = 1.42 ms/TE1: 2.4 ms |
Spotorno et al. [135] | 236 Amyloid-b-positive subjects, 78 cognitively unimpaired, and 158 cognitively impaired patients | 3Â T | 3D multi-echo gradient-echo | 24Â ms | 5.00, 8.80, 12.60, 16.40, and 20.20Â ms |
Spincemaille [139] | 10 Healthy subjects | 3Â T | 3D multi-echo gradient-echo | 24.48Â ms | 5 echoes: 3.85, 7.97, 12.09, 16.21, and 20.33Â ms |
 |  |  |  | 45.08 ms | 10 echoes: 3.85, 7.97, 12.09, 16.21, 20.33, 24.45, 28.57, 32.69, 36.81, and 40.93 ms |
 |  | 7 T | 3D multi-echo gradient-echo | 24.55 ms | 5 echoes: 3.81, 7.91, 12.00, 16.10, and 20.20 ms |
 |  |  |  | 45.03 ms | 10 echoes: 3.81, 7.91, 12.00, 16.10, 20.20, 24.29, 28.39, 32.48, 36.58, and 40.68 ms |
Li et al. [131] | 10 Healthy subjects | 3 T | 3D multi-echo gradient-echo | 40 ms | 6 echoes/ΔTE: 6 ms/TE1: 6 ms |
Gong et al. [92] | 4 Pairs of transgenic mice with abnormal beta amyloid-aggregation (Tg-SwDI) | 7 T | 3D multi-echo gradient-echo | 250 ms | TE1: 3.72 ms /ΔTE: 5.52 ms/TE10: 53.36 ms |
Du et al. [2] | 30 Patients with AD | 3Â T | 3D gradient-echo (GRE) | 22.9Â ms | 3.2Â ms |
Li [129] | 31 Non-demented PD patients, 10 patients with PDD and 27 healthy subjects | 3Â T | SWI with velocity-compensated 3D fast-field echo | TR/TE: 28/23Â ms | Â |
Kim et al. [121] | 19 Patients with aMCI, 19 patients with mild and probable AD, and 19 healthy subjects, | 3 T | 3D fast field-echo (FFE) | 43 ms | TE1: 3.4 ms/ΔTE: 6.0 ms/ TE7: 39 ms |
Wei et al. [140] | 7 Healthy subjects | 3Â T | Standard flow-compensated 3D fast spoiled-gradient-recalled (SPGR) | TR/TE: 50/40Â ms | Â |
Ide et al. [128] | 19 Patients with PD and 41 healthy subjects | 3 T | 3D multi-echo spoiled gradient echo (GRE) | 58.4 ms | 11 echoes/ΔTE: 5 ms/TE1: 4.5 ms |
Moon et al. [133] | 12 Patients with VaD, 27 patients with AD, and 18 healthy subjects | 3 T | Susceptibility-weighted angiography sequence [SWAN] | 37 ms | 8echoes/ΔTE: 4.09 ms/TE1:3.5 ms |
Sun et al. [57] | 6 Healthy subjects | 1.5Â T | Standard gradient recalled echo (GRE) 3D-radiofrequency spoiled GRE | TR/TE: 49/40Â ms | Â |
Acosta-Cabronero et al. [21] | 8 Patients with early-stage probable AD | 3Â T | Susceptibility-weighted-imaging | 35Â ms | 20Â ms |