Network parameter | MRI | HC versus MS total | HC versus RRMS | HC versus PMS | RRMS versus PMS |
---|---|---|---|---|---|
Average degree | Original T1w | 3.17 (− 1.35–7.37) | 3.93 (− 2.68–7.60) | 0.29 (− 4.50–4.61) | − 3.64 (− 6.50–3.59) |
Lesion-filled T1w | 5.16 (− 0.01–2.31)* | 5.17 (− 0.38–2.68)* | 4.48 (− 1.93–1.80)* | − 0.69 (− 2.07–0.29) | |
Average strength | Original T1w | 17.0 (− 17.2–21.4) | 16.0 (− 21.0–23.1) | 14.5 (− 21.5–21.8) | − 1.5 (− 23.0–19.9) |
Lesion-filled T1w | 27.9 (− 15.0–20.0)* | 30.1 (− 20.4–23.4)* | 19.0 (− 18.1–18.5)* | − 11.1 (− 20.3–17.7) | |
Average path length | Original T1w | − 0.46 (− 0.66–0.53) | − 0.46 (− 0.75–0.67) | − 0.40 (− 0.64–0.60) | 0.06 (− 0.63–0.64) |
Lesion-filled T1w | − 0.86 (− 0.57–0.34)* | − 0.92 (− 0.63–0.54)* | − 0.60 (− 0.49–0.46)* | 0.32 (− 0.48–0.55) | |
Global efficiency | Original T1w | 0.11 (− 0.14–0.14) | 0.10 (− 0.16–0.15) | 0.10 (− 0.16–0.16) | 0.00 (− 0.15–0.17) |
Lesion-filled T1w | 0.20 (− 0.12–0.15)* | 0.22 (− 0.17–0.18)* | 0.13 (− 0.14–0.14) | − 0.08 (− 0.15–0.14) | |
Local efficiency | Original T1w | 1.26 (− 1.91–1.78) | 1.16 (− 1.91–1.72) | 1.22 (− 1.93–2.00) | 0.06 (− 1.66–2.01) |
Lesion-filled T1w | 2.33 (− 1.68–2.01)* | 2.60 (− 2.29–2.26)* | 1.50 (− 1.91–2.14) | − 1.10 (− 2.15–2.00) | |
Clustering | Original T1w | 0.17 (− 0.14–0.19) | 0.15 (− 0.18–0.20) | 0.14 (− 0.20–0.19) | − 0.01 (− 0.19–0.17) |
Lesion-filled T1w | 0.26 (− 0.12–0.19)* | 0.28 (− 0.19–0.21)* | 0.17 (− 0.17–0.17) | − 0.11 (− 0.20–0.15) | |
Transitivity | Original T1w | 0.25 (− 0.22–0.30) | 0.22 (− 0.27–0.29) | 0.22 (− 0.28–0.30) | 0.00 (− 0.31–0.26) |
Lesion-filled T1w | 0.39 (− 0.19–0.27)* | 0.42 (− 0.26–0.34)* | 0.26 (− 0.24–0.26) | − 0.16 (− 0.30–0.22) | |
Modularity | Original T1w | − 0.061 (− 0.060–0.014)* | − 0.055 (− 0.054–0.030)* | − 0.045 (− 0.040–0.038)* | 0.010 (− 0.029–0.054) |
Lesion-filled T1w | − 0.071 (− 0.044–0.011)* | − 0.069 (− 0.050–0.028)* | − 0.054 (− 0.026–0.027)* | 0.015 (− 0.017–0.039) | |
Assortativity | Original T1w | 0.047 (− 0.024–0.031)* | 0.028 (− 0.022–0.025)* | 0.034 (− 0.027–0.026)* | 0.007 (− 0.051–0.048) |
Lesion-filled T1w | 0.024 (− 0.001–0.023)* | 0.025 (− 0.008–0.024)* | 0.014 (− 0.019–0.019) | − 0.012 (− 0.018–0.008) | |
Small-worldness | Original T1w | 0.010 (− 0.027–0.064) | 0.019 (− 0.038–0.064) | − 0.011 (− 0.048–0.051) | − 0.030 (− 0.060–0.053) |
Lesion-filled T1w | 0.065 (− 0.011–0.056)* | 0.069 (− 0.028–0.054)* | 0.034 (− 0.039–0.041) | − 0.035 (− 0.053–0.027) |