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Table 3 Differences in global graph theoretical network parameters between groups. The corresponding 95% confidence intervals (CI) are presented between brackets

From: The effect of lesion filling on brain network analysis in multiple sclerosis using structural magnetic resonance imaging

Network parameter

MRI

HC versus MS total

HC versus RRMS

HC versus PMS

RRMS versus PMS

Average degree

Original T1w

3.17

(− 1.35–7.37)

3.93

(− 2.68–7.60)

0.29

(− 4.50–4.61)

− 3.64

(− 6.50–3.59)

Lesion-filled T1w

5.16

(− 0.012.31)*

5.17

(− 0.382.68)*

4.48

(− 1.931.80)*

− 0.69

(− 2.07–0.29)

Average strength

Original T1w

17.0

(− 17.2–21.4)

16.0

(− 21.0–23.1)

14.5

(− 21.5–21.8)

− 1.5

(− 23.0–19.9)

Lesion-filled T1w

27.9

(− 15.020.0)*

30.1

(− 20.423.4)*

19.0

(− 18.118.5)*

− 11.1

(− 20.3–17.7)

Average path length

Original T1w

− 0.46

(− 0.66–0.53)

− 0.46

(− 0.75–0.67)

− 0.40

(− 0.64–0.60)

0.06

(− 0.63–0.64)

Lesion-filled T1w

− 0.86

(− 0.570.34)*

− 0.92

(− 0.630.54)*

− 0.60

(− 0.490.46)*

0.32

(− 0.48–0.55)

Global efficiency

Original T1w

0.11

(− 0.14–0.14)

0.10

(− 0.16–0.15)

0.10

(− 0.16–0.16)

0.00

(− 0.15–0.17)

Lesion-filled T1w

0.20

(− 0.120.15)*

0.22

(− 0.170.18)*

0.13

(− 0.14–0.14)

− 0.08

(− 0.15–0.14)

Local efficiency

Original T1w

1.26

(− 1.91–1.78)

1.16

(− 1.91–1.72)

1.22

(− 1.93–2.00)

0.06

(− 1.66–2.01)

Lesion-filled T1w

2.33

(− 1.682.01)*

2.60

(− 2.292.26)*

1.50

(− 1.91–2.14)

− 1.10

(− 2.15–2.00)

Clustering

Original T1w

0.17

(− 0.14–0.19)

0.15

(− 0.18–0.20)

0.14

(− 0.20–0.19)

− 0.01

(− 0.19–0.17)

Lesion-filled T1w

0.26

(− 0.120.19)*

0.28

(− 0.190.21)*

0.17

(− 0.17–0.17)

− 0.11

(− 0.20–0.15)

Transitivity

Original T1w

0.25

(− 0.22–0.30)

0.22

(− 0.27–0.29)

0.22

(− 0.28–0.30)

0.00

(− 0.31–0.26)

Lesion-filled T1w

0.39

(− 0.190.27)*

0.42

(− 0.260.34)*

0.26

(− 0.24–0.26)

− 0.16

(− 0.30–0.22)

Modularity

Original T1w

− 0.061

(− 0.0600.014)*

− 0.055

(− 0.0540.030)*

− 0.045

(− 0.0400.038)*

0.010

(− 0.029–0.054)

Lesion-filled T1w

− 0.071

(− 0.0440.011)*

− 0.069

(− 0.0500.028)*

− 0.054

(− 0.0260.027)*

0.015

(− 0.017–0.039)

Assortativity

Original T1w

0.047

(− 0.0240.031)*

0.028

(− 0.0220.025)*

0.034

(− 0.0270.026)*

0.007

(− 0.051–0.048)

Lesion-filled T1w

0.024

(− 0.0010.023)*

0.025

(− 0.0080.024)*

0.014

(− 0.019–0.019)

− 0.012

(− 0.018–0.008)

Small-worldness

Original T1w

0.010 (− 0.027–0.064)

0.019 (− 0.038–0.064)

− 0.011 (− 0.048–0.051)

− 0.030 (− 0.060–0.053)

Lesion-filled T1w

0.065 (− 0.011–0.056)*

0.069 (− 0.028–0.054)*

0.034 (− 0.039–0.041)

− 0.035 (− 0.053–0.027)

  1. Differences relative to the healthy controls are statistically significant when the differences fall outside the 95% CI. Significant differences are indicated with an asterisk *. No statistically significant differences were observed between the RRMS and PMS group