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Fig. 6 | Insights into Imaging

Fig. 6

From: Signal enhancement ratio of CE-MRI: a potential biomarker of survival after hepatic arterial infusion chemotherapy in biliary tract cancers

Fig. 6

Two typical case demonstrations of intrahepatic cholangiocarcinoma. AD Images from a 66-year-old male patient with iCCA. A, B The signal enhancement ratio (SER) before the initiation of hepatic arterial infusion chemotherapy (HAIC) was 1.32 [(1202–518)/518]. C, D After two cycles of HAIC, the tumor shrank significantly in size, which corresponded to partial response according to RECIST 1.1. SER of the tumor decreased [SER = (829–495)/495 = 0.67; ΔSER = 1.32–0.67 = 0.65 > 0]. The tumor progressed after 10 months following the initiation of HAIC. Without subsequent treatment after progression, the patient died after 11.2 months of the initiation of HAIC. (E–H) Images from a 76-year-old female patient with iCCA. E, F The SER before the initiation of HAIC was 0.65 [(837–506)/506]. G, H After two cycles of HAIC, the tumor did not change significantly in size, which corresponded to stable disease according to RECIST 1.1. SER of the tumor increased [SER = (600–253)/253 = 1.37; ΔSER = 0.65–1.37 = − 0.72 < 0]. The tumor progressed after 4 months following the initiation of HAIC, and subsequent HAIC with another regimen was performed. The patient died 13.7 months after the initiation of HAIC with 3cir-OFF regimen

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