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Table 2 Characteristics of mammographically occult breast cancers according to the AI analysis

From: Mammographically occult breast cancers detected with AI-based diagnosis supporting software: clinical and histopathologic characteristics

Variable

AI-detected

Undetected

p

Total

40 (31.2)

88 (68.8)

 

Agea

43.6 ± 9.8

50.9 ± 9.3

< 0.001

Malignancy scorea

53.6 ± 24.1

2.7 ± 6.2

< 0.001

Symptom

 Yes

19 (47.5)

16 (18.2)

0.001

 Palpable lump

19 (47.5)

10 (11.4)

 Bloody nipple discharge

0 (0)

6 (6.8)

Family history

0.37

 Yes

4 (10.0)

14 (15.9)

Breast density

0.19

 A

0 (0)

1 (1.1)

 B

1 (2.5)

5 (5.7)

 C

11 (27.5)

38 (43.2)

 D

28 (70.0)

44 (50.0)

Location (Laterality)

0.27

 Right

21 (52.5)

37 (42.0)

 Left

19 (47.5)

51 (58.0)

Location (Quadrant)

0.83

 UOQ

21 (52.5)

47 (53.4)

 UIQ

9 (22.5)

24 (27.3)

 LOQ

5 (12.5)

7 (8.0)

 LIQ

5 (12.5)

10 (11.4)

Ultrasonographic tumor sizea

17.0 ± 10.0

13.4 ± 14.6

0.001

 < 10 mm

8 (20.0)

43 (48.9)

 10–14 mm

13 (32.5)

28 (31.8)

 15–19 mm

6 (15.0)

9 (10.2)

 20–49 mm

12 (30.0)

3 (3.4)

 ≥ 50 mm

1 (2.5)

5 (5.7)

Detectability on MRIb

0.97

 Yes

32 (97.0)

61 (96.8)

Histologic type

0.45

 Ductal carcinoma

34 (85.0)

79 (89.8)

 Lobular carcinoma

4 (10.0)

8 (9.1)

 Mucinous carcinoma

1 (2.5)

1 (1.1)

 Adenoid cystic carcinoma

1 (2.5)

0 (0)

Nuclear grade

0.49

 1

2 (5.0)

9 (10.2)

 2

31 (77.5)

67 (76.1)

 3

7 (17.5)

12 (13.6)

Histologic gradeb

0.51

 1

3 (8.1)

10 (14.9)

 2

27 (73.0)

48 (71.6)

 3

7 (18.9)

9 (13.4)

Molecular subtypeb

0.59

 Luminal A

21 (55.3)

54 (66.7)

 Luminal B

9 (23.7)

17 (21.0)

 HER-2

4 (10.5)

5 (6.2)

 Triple-negative

4 (10.5)

5 (6.2)

Neoadjuvant chemotherapyb

< 0.001

 Yes

12 (32.4)

5 (6.2)

Operation methodb

< 0.001

 Mastectomy

21 (56.8)

18 (22.2)

 Breast-conserving operation

16 (43.2)

63 (77.8)

Invasivenessb

0.04

 DCIS

3 (8.1)

20 (24.7)

 Invasive carcinoma

34 (91.9)

61 (75.3)

Histologic upgradeb

0.44

 Yes

6 (16.2)

9 (11.1)

Invasive tumor sizea,b

12.7 ± 14.1

8.7 ± 9.5

0.93

 < 10 mm

15 (40.5)

47 (58.0)

 10–14 mm

9 (24.3)

18 (22.2)

 15–19 mm

5 (13.5)

6 (7.4)

 20–49 mm

7 (18.9)

10 (12.3)

 ≥ 50 mm

1 (2.7)

0 (0)

Axillary lymph node metastasisb

0.003

 Yes

11 (29.7)

7 (8.6)

  1. Unless indicated otherwise, data are numbers of patients with percentages in parentheses
  2. AI artificial intelligence, UOQ upper outer quadrant, UIQ upper inner quadrant, LOQ lower outer quadrant, LIQ lower inner quadrant, DCIS ductal carcinoma in situ
  3. aValues are the mean ± standard deviation
  4. bPercentages are calculated based on the number of patients who had available data