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Fig. 6 | Insights into Imaging

Fig. 6

From: Multiparametric MRI evaluation of bone sarcomas in children

Fig. 6

Ewing sarcoma involving the sphenoid bone in a 15-year-old boy. a Axial contrast-enhanced fat-suppressed T1-weighted MR image of the orbits shows a heterogeneously hyperintense mass (*) arising from the sphenoid bone with internal necrosis (arrow). b Axial ADC map shows restricted diffusion of the mass (*). c Axial contrast-enhanced fat-suppressed T1-weighted MR image performed after 2 cycles of chemotherapy shows decrease in volume of the mass with heterogeneous enhancement of the residual tumor (*). d Axial ADC maps shows no restriction of the residual mass (*). e Axial contrast-enhanced fat-suppressed T1-weighted MR image performed after 3 cycles of chemotherapy shows residual enhancing tissue (arrow). f Axial ADC map shows no restriction (arrow). g Volumetry of ADC maps performed before (yellow) during (white) and after (purple) treatment. Before chemotherapy, the tumor volume is 12 cc with corresponding high and sharp ADC (yellow) histogram of 0.49 mm2/s. During treatment, the volume does not significantly change (11 cc), but the corresponding volumetric ADC (white) histogram increases to 1.85 mm2/s, appearing short, wide and shifted to the right. After treatment, the volume decreases to 1.35 cc and the ADC (purple) histogram does not change (1.85 mm2/s). Overall, this indicates good treatment response

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