Fig. 4
From: Multiparametric MRI evaluation of bone sarcomas in children
Same patient as in Fig. 3a Axial DCE-MR image (left) with corresponding time intensity curve (TIC) (right) before treatment shows early peripheral enhancement of the tumor (long arrows), which correlates with types III and IV TIC (green curve) and no enhancement of the central part of the tumor (thick arrow), which correlates with a type I TIC (horizontal orange curve), suggestive of necrosis. Peritumoral edema (short arrow) correlates with a type II TIC (pink curve). The blue curve represents the arterial TIC. b Axial DCE-MR image (left) with corresponding TIC (right) after treatment shows enhancement of the residual tumor (short arrow), which correlates with a type III TIC (orange curve). There is no change of the tumor necrosis (green curve) or peritumoral edema (pink curve). c Volumetry and d histogram of ADC maps performed before and after treatment shows an increase of the ADC mean values from 1.22 mm2/s to 1.41 mm2/s. e) ADC image after treatment shows residual tumor (short arrows)