CMR Characteristics, gene variants and long-term outcome in patients with left ventricular non-compaction cardiomyopathy

Zhou, Di; Li, Shijie; Sirajuddin, Arlene; Wu, Weichun; Huang, Jinghan; Sun, Xiaoxin; Zhao, Shihua; Pu, Jielin; Lu, Minjie

doi:10.1186/s13244-021-01130-2

Insights into Imaging

Table 2 Cardiac magnetic resonance data

From: CMR Characteristics, gene variants and long-term outcome in patients with left ventricular non-compaction cardiomyopathy

Parameters	LVNC (n = 28)	G+ (n = 11)	G− (n = 17)	p value*
LVEF, %	34.2 ± 17.6	32.6 ± 17.0	35.2 ± 18.4	0.703†
LVEDVi, ml/m²	133.4 ± 52.3	124.5 ± 42.6	139.2 ± 58.3	0.479
LVESVi, ml/m²	93.7 ± 56.5	77.9 (59.0, 121.3)	67.5 (44.8, 146.3)	0.733
LVSVi, ml/m²	39.7 ± 17.6	35.4 ± 17.4	42.4 ± 17.7	0.832
LVCI, l/min·m²	2.3 (1.5, 2.9)	2.0 (1.5, 3.7)	2.8 (2.1, 3.8)	0.384†
LV-C, mm	4.9 ± 1.2	5.3 ± 1.4	4.6 ± 1.0	0.123
LV-NC, mm	14.4 ± 4.0	16.1 ± 4.6	13.4 ± 3.4	0.084
LV-NC/C	2.9 (2.5, 3.3)	2.8 (2.7, 3.2)	2.8 (2.5, 3.2)	0.944
LVMi-C, g/m²	64.5 ± 16.7	58.2 ± 13.8	68.6 ± 17.5	0.107
LVMi-NC, g/m²	63.9 ± 24.9	66.4 ± 25.5	62.2 ± 25.2	0.671
LVMi-MM, g/m²	128.4 ± 37.4	124.6 ± 33.8	130.9 ± 40.3	0.674
LVMi-NC/MM	0.5 ± 0.1	0.5 (0.5, 0.6)	0.5 (0.4, 0.5)	0.070
LGE, %	13.5 ± 11.2	17.3 ± 13.6	11.2 ± 9.4	0.258†
LGE, n (%)	19 (67.9)	7 (70)	12 (66.7)	> 0.99
Myocardial deformation
LVGLS, %	− 12.8 ± 5.2	− 11.6 ± 3.9	− 13.5 ± 5.8	0.350
LVGCS, %	− 16.9 ± 9.5	− 13.5 (− 16.0, − 6.2)	− 22.4 (− 25.8, − 9.1)	0.466†
LVGRS, %	22.2 (12.6, 45.1)	28.4 ± 25.9	29.4 ± 19.2	0.910
LAVmax, ml	66.7 (45.2, 130.5)	116.7 ± 61.7	66.6 ± 37.8	0.029†
LAVpre-a, ml	51.4 (33.9, 102.4)	93.7 ± 54.4	52.4 ± 32.2	0.048†
LAVmin, ml	30.2 (18.2,92.5)	69.7 (25.8, 128.1)	22.7 (12.4, 61.9)	0.013†
LAEFtotal, %	43.9 (29.0, 64.4)	37.6 ± 17.4	51.3 ± 18.9	0.066†
LAEFpassive, %	22.0 ± 10.8	20.7 ± 9.7	22.8 ± 11.7	0.623
LAEFactive, %	24.3 (12.3, 51.5)	18.1 (11.4, 46.8)	34.8 (13.0, 59.1)	0.120†
εs, %	21.8 (13.9, 42.8)	17.2 (12.6, 36.7)	31.4 (19.8, 47.2)	0.115†
εe, %	12.6 ± 10.6	10.2 ± 6.6	14.2 ± 12.4	0.281
εa, %	11.9 (5.6, 21.2)	12.5 ± 9.1	19.2 ± 13.8	0.134†

Data are expressed as mean ± SD (standard deviation) or median (inter-quartile range)
LVNC left ventricular non-compaction cardiomyopathy, G+ genotype positive, G- genotype negative, LVEF left ventricular ejection fraction, LVEDVi LV end-diastolic volume index, LVESVi LV end-systolic volume index, LVSVi LV stroke volume index, LVCI LV cardiac index, C compacted thickness, NC non-compacted thickness, NC/C the ratio of non-compacted and compacted myocardial thickness, LVMi-C LV end-diastolic compacted mass index, LVMi-NC LV end-diastolic indexed NC mass, LVMi-MM indexed global LV myocardial mass, LVMi-NC/MM the ratio of non-compacted and global myocardial mass, LGE late gadolinium enhancement, GLS global longitudinal strain, GCS global circumferential strain, GRS global radial strain, LAVmax maximal left atrial volume, LAVpre-a left atrial volume before LA contraction, LAVmin minimal left atrial volume, LAEF left atrial emptying fraction, εs total strain, εe passive strain, εa active strain
*Significance of difference between parameters from G+ and G− groups
^†Significance of difference between parameters from carriers of multiple variants and G- group

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