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Insights into Imaging
Fig. 2 | Insights into Imaging

Fig. 2

From: Using amide proton transfer-weighted MRI to non-invasively differentiate mismatch repair deficient and proficient tumors in endometrioid endometrial adenocarcinoma

Fig. 2

A 56-year-old woman with post-menopause uterus bleeding and mismatch repair deficient (dMMR) endometrioid endometrial adenocarcinoma (EEA), grade 3 with stage IA. MR images of: a T2WI; b APTw, with mean APTw value 3.0% by two readers; c DWI original map (b = 1000 s/mm2); d pseudo colored map of ADC, with mean ADC values 0.721 × 10−3 mm2/s by two readers. MMR immunohistochemistry analysis revealed the loss of nuclear staining in tumor cells for MLH1 (e) and PMS2 (f), respectively (×100 magnification); positive staining in stromal cells and normal endometrial glands serves as internal control. Loss of MSH2 (g) and MSH6 (h) expression, respectively (×100 magnification). Brown stain is positive staining and blue counterstain is indicative of absent or negative staining

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