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Table 9 DWI parameters after NST

From: Factors affecting the value of diffusion-weighted imaging for identifying breast cancer patients with pathological complete response on neoadjuvant systemic therapy: a systematic review

First author ADC-value (× 10−3 mm2/s)
pCR versus non-pCRa
Reported/chosen ADC threshold for pCR (× 10−3 mm2/s) ROC AUC (95% CI) Sens (%) Spec (%) PPV (%) NPV (%)
Shin [26] 1.43 (1.24, 1.69) versus 1.10 (0.93, 1.23) p = 0.003 1.19 0.80 (0.62, 0.94) 100 70   
Santamaria [27] 1.812 ± 0.294 versus 1.563 ± 0.471 p = 0.011 n.r.      
Hahn [67]   1.10 ± 0.54 versus 0.92 ± 0.33 p = 0.130   65.0 91.4 72.2 88.3
Liu (broad pCR-definition) [16] Luminal A: 1.39 ± 0.07 versus 1.15 ± 0.09 p < 0.001 Luminal A: 1.35 0.864 75.0 96.6 75.0 96.6
  Luminal B: 1.41 ± 0.12 versus 1.17 ± 0.07 p < 0.001 Luminal B: 1.33 0.857 71.4 97.4 71.4 94.9
  HER2 enriched: 1.39 ± 0.07 versus 1.24 ± 0.08 p < 0.001 HER2-enriched: 1.38 0.792 62.5 95.2 83.3 87.0
  TN: 1.44 ± 0.09 versus 1.33 ± 0.06 p < 0.001 TN: 1.43 0.751 66.7 82.6 66.7 82.6
Woodhams [64] Visual assessmentb Visual Visual 89 97 80 98
  1. ADC apparent diffusion coefficient, HER2 human epidermal growth factor receptor 2, CI confidence interval, pCR pathological complete response, Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, TN triple negative
  2. aMean ADC-value ± SD with the exception of Shin et al. [26]: median ADC and the interquartile range
  3. bResidual disease was defined positive in full-text, in the table above pCR is defined positive. PPV and NPV were calculated from extracted data of the full-text. Performance regarding visual assessment. Post-NST ADC-values could not be extracted for the whole study population