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Table 4 Studies classified by pCR-definition

From: Factors affecting the value of diffusion-weighted imaging for identifying breast cancer patients with pathological complete response on neoadjuvant systemic therapy: a systematic review

pCR-definition/first author pCR rate (95% CI) Na Totalb
No invasive. No DCIS
Santamaria [27] 0.19 (0.12–0.26) 21 111
Minarikova (baseline) [59] 0.17 (0.05–0.28) 7 42
Minarikova (after 5 cycles) [59] 0.15 (0.03–0.27) 5 33
Woodhams [64]c 0.13 (0.05–0.21) 9 70
No invasive. DCIS may be present
Che [19] 0.19 (0.07–0.32) 7 36
Bedair [20] 0.39 (0.23–0.55) 14 36
Fangberget [65] 0.37 (0.19–0.54) 11 30
Shin [26] 0.37 (0.22–0.51) 15 41
Hahn [67] 0.24 (0.15–0.34) 19 78
Yuan [22] 0.28 (0.21–0.36) 40 142
Partridge (pre) [23] 0.31 (0.25–0.37) 71 227
Partridge (mid) [23] 0.33 (0.27–0.40) 70 210
Partridge (post) [23] 0.34 (0.27–0.41) 63 186
Gallivanone [21]d 0.42 (0.25–0.59) 13 31
Fujimoto [66] 0.14 (0.05–0.23) 8 56
Woodhams [64]e 0.13 (0.23–0.33) 16 70
Pereira [18] 0.39 (0.27–0.51) 24 62
No invasive (without specification)
Bufi [17] 0.17 (0.12–0.22) 39 225
Ramirez-Galván [25]f 0.25 (0.04–0.46) 4 16
Li [44] 0.33 (0.19–0.48) 14 42
Near pCR
Liu [16]g 0.18 (0.12–0.24) 32 176
Kim [53]g 0.30 (0.17–0.44) 14 (5: real pCR) 46
No definition for pCR
Tozaki [40] 0.14 (0–0.40) 1 7
  1. pCR pathologic complete response, DCIS ductal carcinoma in situ, CI confidence interval
  2. aLesions/patients with a pCR
  3. bTotal lesions/patients
  4. cData extracted from supplementary material
  5. dCalculated from 42% pCR from full-text
  6. eBroader pCR-definition including DCIS, in addition to original pCR-definition in full-text. Data extracted by supplementary materials
  7. fMiller and Payne grade 5
  8. gMiller and Payne 4 included, in Kim et al. [53] was labeled as good responders