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Table 2 Comparison of CT features between L-PLADC and D-PLADC

From: Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics

CT Features Patients with L-PLADC (n = 131) Patients with D-PLADC (n = 117) p valuea
Distribution    
 Single lobe 131/131 (100%) 36/117 (21.1%)
  Right upper lobe 49/131 (37.4%) 6/117 (5.1%)
  Right middle lobe 12/131 (9.2%) 0/117 (0%)
  Right lower lobe 22/131 (16.8%) 14/117 (12.0%)
  Left upper lobe 35/131 (26.7%) 6/117 (5.1%)
  Left lower lobe 13/131 (9.9%) 10/117 (8.5%)
 Right multiple lobes 0/131 (0%) 20/117 (17.1%)  
 Left multiple lobes 0/131 (0%) 5/117 (4.3%)
 Bilateral multiple lobes 0/131 (0%) 56/117 (47.9%)
Interlobular fissure bulging 8/131 (6.1%) 48/117 (41.0%) < 0.001a
Hypodense sign b 22/82 (26.8%) 79/88 (89.8%) < 0.001a
Air space 40/131 (30.5%) 68/117 (58.1%) < 0.001a
Irregular air bronchogram 90/131 (68.7%) 81/117 (69.2%) 0.928 a
CT angiogram sign b 22/82 (21.8%) 79 /88 (89.8%) < 0.001b
GGO 101/131 (77.1%) 94/117 (80.3%) 0.534a
Coexisting nodules 15/131 (11.5%) 73/117 (62.4%) < 0.001a
Pleural retraction 102/131 (77.9%) 8/117 (6.8%) < 0.001a
Pleural effusion 6/131 (4.6%) 72/117 (61.5%) < 0.001a
Lymphadenopathy 13/131 (9.9%) 53/117 (45.3%) < 0.001a
  1. CT, computed tomography; L-PLADC, localized pneumonic-type lung adenocarcinoma; D-PLADC, diffuse pneumonic-type lung adenocarcinoma; GGO, ground-glass opacity
  2. aChi-squared test
  3. bHypodense sign and CT angiogram sign was not assessed in 78 patients who did not undergo contrast-enhanced scanning